Gene GADD45* map

Identifiers
Growth arrest and DNA-damage-inducible, alpha
HUGO:GADD45A, HGNC:4095, ENTREZ:1647
DDIT1
HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522
growth arrest and DNA-damage-inducible beta
MYD118
HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293
HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 GENECARDS:GADD45A KEGG:1647 ATLASONC:GC_GADD45A WIKI:GADD45A
HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 GENECARDS:GADD45B KEGG:4616 ATLASONC:GC_GADD45B WIKI:GADD45B
growth arrest and DNA-damage-inducible gamma
HUGO:GADD45G HGNC:4097 ENTREZ:10912 UNIPROT:O95257 GENECARDS:GADD45G KEGG:10912 ATLASONC:GC_GADD45G WIKI:GADD45G

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / NER  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:19004803
CyclinB1/CDC2 (CDK1) complex is inhibited by GADD45 in responce to DNA damage and causes G2/M arrest
PMID:12124778, PMID:19652693, PMID:15917306
PMID:20025601
PMID:20673124

gGADD45*@Nucleus

References
ce_re226( Cell Cycle DNA Repair  map ):
BRCA1 up-regulates transcription of GADD45 in p53 independed manner:
PMID:10367887, PMID:10962562
PMID:19004803, PMID:12496474
p53 enhances transcription of GADD45:
PMID:9892649, PMID:10779360
p53 regulated global genomic NER at the level of DNA damage recognition involving GADD45, XPC, DDB2:
PMID:12771027, PMID:9346961

Modifications:
In compartment: Nucleus
  1. gGADD45*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gGADD45*@Nucleus map → map rGADD45*@Nucleus map
    2. gGADD45*@Nucleus map → map rGADD45*@Nucleus map
    3. p53*|​pho@Nucleus map → map gGADD45*@Nucleus map
    4. gGADD45*@Nucleus map → map GADD45*@Cytoplasm map
    5. su_mpk1_mpk1_s1028 → map gGADD45*@Nucleus map
    6. su_mpk1_mpk1_s1027 → map gGADD45*@Nucleus map
    As Catalyser: