CTIP*

Protein CTIP*

Identifiers
retinoblastoma binding protein 8 (RIM)
CTBP-interacting protein (CtIP)
HUGO:RBBP8, HGNC:9891, ENTREZ:5932, UNIPROT:Q99708

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / G1_S_CHECKPOINT
Cell Cycle DNA Repair / G2_M_CHECKPOINT
Cell Cycle DNA Repair / A_NHEJ

References
PMID:17965729, PMID:9721205, PMID:19202191, PMID:18171986, PMID:20723763
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550

CTIP*|emp|S372_pho|T847_pho|S267_pho@Nucleus

References
ce_re110( Cell Cycle DNA Repair ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
ce_re118( Cell Cycle DNA Repair ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644

References
ce_re118( Cell Cycle DNA Repair ):
BRCA1 ubiquitinates CtIP that allows propagation through G2 to M checkpoint
PMID:16818604
PMID:19357644
ce_re121( Cell Cycle DNA Repair ):
The shift from C_NHEJ to HR is regulated by the CtIP and BRCA1. CDK1-dependent phosphorylation of CtIP regulates the shift: PMID:19357644
PMID:15485915

CTIP*|ubi@Nucleus

References
ce_re111:( Cell Cycle DNA Repair ) PMID:14654780

CTIP*|emp@Nucleus

References
ce_re110( Cell Cycle DNA Repair ):
Phosphorylation by ATM and ATR at T847, S327
Phosphorylation at S327 by ATM and ATR are essential for shift from A_NHEJ to HR
Phosphorylation by CDC2(CDK1) in cell cycle dep manner to shift from C_NHEJ ot HR at: Ser 267
This phosphorylation allows resection that initiates HR and blocks binding of Ku70/Ku80 complex that initiates C_NHEJ.
PMID:19357644, PMID:15485915, PMID:19490890, PMID:18716619 (for CDK-dep phosph), PMID:20051983
BRCA1 and CtIP interactions make shift from A_NHEJ and C_NHEJ toward HR
Resected DNA in HR is a positive trigger for amplification of the HR pathway (positive loop):
PMID:20051983
Only when CDKs are fully active, this fully activates HR during S and G2 phases:
PMID:18511906, PMID:18716619
ce_re111:( Cell Cycle DNA Repair ) PMID:14654780
ce_re122( Cell Cycle DNA Repair ):
PMID:20064462,
MRN complex in A_NHEJ: PMID:19362533, PMID:19654615, PMID:19892829

Modifications:
In compartment: Nucleus

CTIP*|emp@Nucleus
CTIP*|ubi@Nucleus
CTIP*|emp|S372_pho|T847_pho|S267_pho@Nucleus
CTIP*|emp|S372_pho|T847_pho|S267_pho|BRCA1-dep_ubi@Nucleus

Participates in complexes:
In compartment: Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser: