Identifiers
breast cancer 2, early onset, FANCD1
HUGO:BRCA2, HGNC:1101, ENTREZ:675, UNIPROT:P51587
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair / HR
Cell Cycle DNA Repair / FANCONI
References
For HR pathway
PMID:19772495, PMID:16697054, PMID:19847258
For Fanconi anemia pathway
PMID:19686080, PMID:19622404, PMID:18931676
References
ce_re120( Cell Cycle DNA Repair ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
ce_re166( Cell Cycle DNA Repair ):
Fanconi recognition complex as FA core complex recruits NER, HR, TLS proteins that collectively repair the ICL. If Fanconi proteins participating in the recognition are dysactivated, there is no any other mechanism to recognize ILSs, therefore, even if NER, HR and TLS are correct, they will not perform the repair without core Fanconi proteins.
PMID:19686080
ce_re203( Cell Cycle DNA Repair ):
The complex activates HR
PMID:18212739
+ DSS1*@Nucleus → BRCA2:DSS1*@Nucleus
+ BARD1:BRCA1@Nucleus + RAD52@Nucleus + BRCA2:DSS1*@Nucleus + FANCN*@Nucleus + FANCD2|K561_ubi|pho@Nucleus + BRIT1*@Nucleus + SFPQ@Nucleus → BARD1:BRCA1:BRCA2:BRIT1*:DSS1*:FANCD2|K561_ubi|pho:FANCN*:RAD51:RAD52:SFPQ:XRCC2:XRCC3@Nucleus
+ BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho|active@Nucleus + BRCA2@Nucleus + NBS1*|S343_pho@Nucleus + RAD51@Nucleus + PCNA@Nucleus + H2AFX|S139_pho|ubi@Nucleus + TIP60*@Nucleus → BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
+ BRCA2@Nucleus + FANCJ*@Nucleus + RPA1:RPA2:RPA3@Nucleus + FANCN*@Nucleus + FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho@Nucleus → BRCA1:BRCA2:FANCD2|K561_ubi|pho:FANCI|K523_ubi|pho:FANCJ*:FANCN*@Nucleus
+ BRCA2@Nucleus + XRCC3@Nucleus + FANCC@Nucleus → BRCA2:FANCC:FANCG|S7_pho:XRCC3@Nucleus
→ BRCA1:BRCA2:FANCD2|pho:FANCI|pho:H2AFX|S139_pho|ubi:NBS1*|S343_pho:PCNA:RAD51:TIP60*@Nucleus
→ BRCA1:BRCA2:FANCD2|pho:FANCI|pho:FANCJ*:FANCN*@Nucleus