Reaction state_transition ce_re48
p53*@Nucleus
→ degraded
Reaction regulators:
- Catalysis
- MDM2@Nucleus
- Inhibition
- BRCA1|S988_pho|S1387_pho|S1423_pho|S1497_pho|S1524_pho|active@Nucleus
References
BRCA1 stabilises p53 and causes activation of p53-dependent DNA-repair genes and activation of checkpoint, but no apoptoss:
PMID:12024039 , PMID:12496474