Protein CHEK1 map

Identifiers
CHK1 checkpoint homolog (S. pombe)
HUGO:CHEK1, HGNC:1925, ENTREZ:1111, UNIPROT:O14757

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G1_S_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map

References
For S-phase checkpoint
PMID:15459660, PMID:17384638, PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221, PMID:18677104
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197

CHEK1@Nucleus

References
ce_re33:( Cell Cycle DNA Repair  map ) PMID:15485915

Modifications:
In compartment: Nucleus
  1. CHEK1@Nucleus map
  2. CHEK1|​pho|​active@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map
  2. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map
  3. ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. CHEK1@Nucleus map → map CHEK1|​pho|​active@Nucleus map
  2. HCLK2*@Nucleus map + CLSPN|​pho@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​HCLK2*@Nucleus map
  3. TIM1*@Nucleus map + CLSPN|​pho@Nucleus map + PCNA|​K164_ubi@Nucleus map + ATRIP:​ATR|​pho@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​PCNA|​K164_ubi:​TIM1*@Nucleus map
  4. ATRIP:​ATR|​pho:​CLSPN|​pho@Nucleus map + TIPIN@Nucleus map + TIM1*@Nucleus map + CHEK1|​pho|​active@Nucleus map → map ATRIP:​ATR|​pho:​CHEK1|​pho:​CLSPN|​pho:​TIM1*:​TIPIN@Nucleus map
  5. rCHEK1@Nucleus map → map CHEK1@Nucleus map
As Catalyser:
  1. S phase@Nucleus map → map G2 phase@Nucleus map
  2. FANCI@Nucleus map → map FANCI|​pho@Nucleus map
  3. gDamaged_DNA*@Nucleus map → map gRepaired_DNA*@Nucleus map
  4. FANCA@Nucleus map → map FANCA|​pho@Nucleus map
  5. FANCD2@Nucleus map → map FANCD2|​pho@Nucleus map
  6. FANCE@Nucleus map → map FANCE|​S376_pho|​T346_pho@Nucleus map
  7. FANCG@Nucleus map → map FANCG|​S7_pho@Nucleus map
  8. CDC25C@Nucleus map → map CDC25C|​S216_pho@Nucleus map
  9. p53*@Nucleus map → map p53*|​pho|​ace|​active@Nucleus map
  10. ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*@Nucleus map + MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7@Nucleus map + CDT1@Nucleus map + CDC6@Nucleus map + CDC45@Nucleus map + POLA*@Nucleus map + PRIM*@Nucleus map + RPA1@Nucleus map + RPA2@Nucleus map + RPA3@Nucleus map → map CDC45:​CDC6:​CDT1:​MCM2:​MCM3:​MCM4:​MCM5:​MCM6:​MCM7:​ORC1*:​ORC2*:​ORC3*:​ORC4*:​ORC5*:​ORC6*:​POLA*:​PRIM*@Nucleus map
  11. No DNA replicarion@Nucleus map → map DNA replicarion@Nucleus map
  12. WEE1@Nucleus map → map WEE1|​CHEK1site_pho@Nucleus map
  13. CDC25A@Nucleus map → map CDC25A|​S76_pho|​S178_pho|​S124_pho|​S279_pho|​S293_pho@Nucleus map
  14. CDC25B@Nucleus map → map CDC25B|​S230_pho|​S151_pho|​S323_pho@Nucleus map
  15. DNA-PK*@Nucleus map → map DNA-PK*|​pho@Nucleus map