Complex BARD1:BRCA1:BRCA2:BRIT1*:DSS1*:FANCD2:FANCN*:RAD51:RAD52:SFPQ:XRCC2:XRCC3
Complex composition:
- RAD52
- FANCN*
- FANCD2
- XRCC2
- XRCC3
- RAD51
- DSS1*
- BRCA2
- BRCA1
- BARD1
- BRIT1*
- SFPQ
BARD1:BRCA1:BRCA2:BRIT1*:DSS1*:FANCD2|K561_ubi|pho:FANCN*:RAD51:RAD52:SFPQ:XRCC2:XRCC3@Nucleus
Identifiers
NAME:BARD1:BRCA1:BRCA2:BRIT1*:DSS1*:FANCD2:FANCN*:RAD51:RAD52:SFPQ:XRCC2:XRCC3
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair
/ HR
References
ce_re146( Cell Cycle DNA Repair
):
Link between Fanconi and HR:
PMID:15650050, PMID:19686080
ce_re136( Cell Cycle DNA Repair
):
Regulation of HR DNA repair foci formation regulation by UBc13:
PMID:17349954
For role of SMARCAL1/RPA in stalled relication fork repair and in the homologous recombination:
PMID:19841479, PMID:19793861, PMID:19793862
MCM8*/MCM9* colocolize at RAD51 filament and reqired for interstrand crosslinks repair
PMID:22771115
Modifications:
Participates in complexes:
In compartment: Nucleus
- BARD1:BRCA1:BRCA2:BRIT1*:DSS1*:FANCD2|K561_ubi|pho:FANCN*:RAD51:RAD52:SFPQ:XRCC2:XRCC3@Nucleus
Participates in reactions:
As Reactant or Product:- RAD51:XRCC2:XRCC3@Nucleus
+ BARD1:BRCA1@Nucleus
+ RAD52@Nucleus
+ BRCA2:DSS1*@Nucleus
+ FANCN*@Nucleus
+ FANCD2|K561_ubi|pho@Nucleus
+ BRIT1*@Nucleus
+ SFPQ@Nucleus
→
BARD1:BRCA1:BRCA2:BRIT1*:DSS1*:FANCD2|K561_ubi|pho:FANCN*:RAD51:RAD52:SFPQ:XRCC2:XRCC3@Nucleus
As Catalyser:- gHR_DNA_st2*@Nucleus
→
gHR_DNA_st3*@Nucleus