Complex CNA*:CNB*
Complex composition:
- CNA*
- CNB*
CNA*:CNB*@INNATE_IMMUNE_CELL_Cytosol
Identifiers
NAME:CNA*:CNB*
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Innate Immunity
/ IMMUNOSTIMULATORY_CORE_PATHWAYS
References
CASCADE:Fc_gamma_RIII
NATURAL_KILLER
PMID:10089876, PMID:7650486, PMID:9973469
??Ca('2+)??activates Calmodulin 2 (??Calmodulin??)/ Protein phosphatase 3 (Calcineurin??) signal. Activated??Calcineurin??dephosphorylates Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2 (??NF-AT1(NFATC2)??).??
This signaling is activated downstream of CD16 in NK cells
CNA*:CNB*@T_cell
Identifiers
NAME:CNA*:CNB*
References
PMID:10089876 PMID:7650486 PMID:9973469
CNA*:CNB*@Nucleus
Identifiers
NAME:CNA*:CNB*
References
s_wnc3_re31( Survival
):
Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription
PMID15657416
Not sure if dissociation of calcineurin and ERK/MEK occurs
Modifications:
Participates in complexes:
In compartment: INNATE_IMMUNE_CELL_Cytosol
- CNA*:CNB*@INNATE_IMMUNE_CELL_Cytosol
In compartment: Nucleus
- CNA*:CNB*@Nucleus
In compartment: T_cell
- CNA*:CNB*@T_cell
Participates in reactions:
As Reactant or Product:- Ca2+:Calmodulin*@T_cell
+ CNA*:CNB*@T_cell
→
CNA*:CNB*:Ca2+:Calmodulin*@T_cell
- Ca2+:Calmodulin*@INNATE_IMMUNE_CELL_Cytosol
+ CNA*:CNB*@INNATE_IMMUNE_CELL_Cytosol
→
CNA*:CNB*:Ca2+:Calmodulin*@INNATE_IMMUNE_CELL_Cytosol
- CNA*:CNB*:NFAT*@Nucleus
→
CNA*:CNB*@Nucleus
+ NFAT*@Nucleus
- CNA*:CNB*:ERK2*:MEK1*:NFAT*|pho@Nucleus
+ gAP-1_ARRE binding sites*@Nucleus
+ JUN@Nucleus
+ FOS@Nucleus
→
AP-1_ARRE binding sites*:NFAT*@Nucleus
+ CNA*:CNB*@Nucleus
+ ERK2*@Nucleus
+ MEK1*@Nucleus
As Catalyser: