Identifiers
HUGO:GSK3B HUGO:GSK3A
HUGO:GSK3A
HUGO:GSK3B
glycogen synthase kinase 3 alpha
HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A
glycogen synthase kinase 3 beta
HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
PMID:19836308 PMID:26885856 PMID:23732914
PMID:16713974
AKT kinases phosphorylate GSK3 proteins and inhibit its activity downstream of TLR signaling.
IFNG prevents this inactivation.
PMID:19366350

References
in_re1149( Innate Immunity  ):
PMID:16713974
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.

References
su_wnc1_s_wnc2_re46( Survival  ):
Upon Ca2+ activation the NRON-NFAT complex dissociates.
PMID:21709260
su_wca1_s_wca1_re19:( Survival  ) PMID:17318175
su_wnc1_s_wnc1_re44( Survival  ):
PKA phosphorylates first Thr1548? followed by GSK3 at S1544
PMID:21406690
su_wca1_s_wca1_re39:( Survival  ) PMID:21606194

References
s_wnc2_re58:( Survival  ) PMID:16511445, PMID:15121840
s_wnc4_re13:( Survival  ) PMID:19131971
s_wnc4_re19:( Survival  ) PMID:22745173

References
s_wnc4_re20:( Survival  ) PMID:22745173

References
s_wca1_re19:( Survival  ) PMID:17318175
s_wnc2_re46( Survival  ):
Upon Ca2+ activation the NRON-NFAT complex dissociates.
PMID:21709260
s_wca1_re39:( Survival  ) PMID:21606194
s_wnc1_re44( Survival  ):
PKA phosphorylates first Thr1548? followed by GSK3 at S1544
PMID:21406690

1. GSK3*@Cytoplasm
2. GSK3*@Cytoplasm
3. GSK3*@Cytoplasm

1. GSK3*@INNATE_IMMUNE_CELL_Cytosol

1. GSK3*@Nucleus
2. GSK3*@Nucleus

1. GSK3*@T_cell
2. GSK3*|​pho@T_cell

1. APC2*:​GSK3*@Cytoplasm
2. AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm
3. AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm
4. APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm
5. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm
6. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
7. APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm
8. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
9. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_emp|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
10. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
11. CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm
12. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm
13. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm
14. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm
15. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm
16. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm
17. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
18. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
19. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
20. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
21. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
22. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
23. APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm
24. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
25. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
26. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
27. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm

1. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome
2. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
3. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
4. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome
5. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
6. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
8. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
9. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
10. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
11. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome

1. AXIN1:​GSK3*:​MYC|​S62_pho:​PIN1@Nucleus
2. AXIN1:​GSK3*:​MYC|​S62_emp|​T58_pho:​PIN1@Nucleus
3. AXIN1:​GSK3*:​MYC|​S62_pho|​T58_pho:​PIN1@Nucleus

1. GSK3*@T_cell → GSK3*|​pho@T_cell
2. GSK3_alpha_*@INNATE_IMMUNE_CELL_Cytosol → GSK3*@INNATE_IMMUNE_CELL_Cytosol
3. GSK3_beta_*@INNATE_IMMUNE_CELL_Cytosol → GSK3*@INNATE_IMMUNE_CELL_Cytosol
4. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm + _beta_-Catenin*@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm
5. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
6. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_emp|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
7. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_emp|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
8. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm + PPP1C*:​PPP1R*@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm
9. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm → APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm
10. APC:​AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm → GSK3*@Cytoplasm + AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm + PPP1C*:​PPP1R*@Cytoplasm
11. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm
12. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm + PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
13. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm
14. APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm → PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm + _beta_-Catenin*@Cytoplasm + AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
15. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm
16. AMER1*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Vaceolae + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
17. AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm + APC@Cytoplasm + AMER1*@Cytoplasm → AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
18. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
19. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
20. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
21. CK1_alpha_*@Cytoplasm + AXIN*@Cytoplasm + GSK3*@Cytoplasm → AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm
22. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm
23. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
24. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
25. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome → CK1_epsilon_*:​p120*|​S268_pho|​S269_pho@Endosome + E-Cadherin*|​pho@Endosome + AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome
26. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome → AMER1*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho|​pho:​FZD*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*@Endosome + AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome
27. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm
28. GTP:​G_alpha_o*@Cytoplasm + AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm + _beta_-Arrestin2*@Cytoplasm → AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Cytoplasm
29. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm
30. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm → CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​NEDD8:​PKD*:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_TRCP*@Cytoplasm + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm
31. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho@Cytoplasm → AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
32. AMER1*:​APC:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
33. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome → Recycling @Cytoplasm
34. AXIN*:​CK1_alpha_*:​GSK3*:​G_alpha_o*:​_beta_-Arrestin2*@Endosome → Degradation@Cytoplasm
35. AMER1*:​APC|​S1505_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
36. AMER1*:​APC|​S1505_pho|​S1501_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
37. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm
38. APC|​K63_ubi@Cytoplasm + AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm → APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm
39. APC|​K63_ubi:​AXIN*:​CK1_alpha_*:​GSK3*@Cytoplasm → WNT canonical pathway@Cytoplasm
40. APC2*:​GSK3*@Cytoplasm + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
41. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome + WGEF*@Cytoplasm + DAAM1@Cytoplasm + RHOA@Cytoplasm → APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm
42. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → Angiogenesis@Nucleus
43. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm → APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm + RHOA@Cytoplasm
44. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → WNT canonical pathway@Cytoplasm
45. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
46. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome
47. CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm → NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm + IQGAP*@Cytoplasm + DYRK*@Cytoplasm + CK1_epsilon_*@Cytoplasm + rNRON@Cytoplasm + GSK3*@Cytoplasm
48. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm → CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm
49. MYC|​S62_pho@Nucleus + AXIN1@Nucleus + GSK3*@Nucleus + PIN1@Nucleus → AXIN1:​GSK3*:​MYC|​S62_pho:​PIN1@Nucleus
50. AXIN1:​GSK3*:​MYC|​S62_pho:​PIN1@Nucleus → AXIN1:​GSK3*:​MYC|​S62_pho|​T58_pho:​PIN1@Nucleus
51. AXIN1:​GSK3*:​MYC|​S62_pho|​T58_pho:​PIN1@Nucleus → AXIN1:​GSK3*:​MYC|​S62_emp|​T58_pho:​PIN1@Nucleus
52. AXIN1:​GSK3*:​MYC|​S62_emp|​T58_pho:​PIN1@Nucleus → MYC|​S62_emp|​T58_pho@Nucleus + AXIN1@Nucleus + PIN1@Nucleus + GSK3*@Nucleus
53. GSK3*@Nucleus → GSK3*@Nucleus

1. NFAT*@T_cell → NFAT*|​pho@T_cell
2. DPYSL2@T_cell → DPYSL2|​Thr509/514_pho@T_cell
3. rTBX21@T_cell → TBX21@T_cell
4. AP1*@INNATE_IMMUNE_CELL_Cytosol → AP1*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
5. _beta_-Catenin*@INNATE_IMMUNE_CELL_Cytosol → _beta_-Catenin*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
6. AMER1*:​APC:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome
7. AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*@Endosome → AMER1*:​AXIN*:​CK1_alpha_*:​CK1_epsilon_*:​CK1_gamma_*:​DVL*|​pho|​pho|​pho:​E-Cadherin*|​pho:​FZD*:​GSK3*:​G_alpha_o*:​G_beta_*:​G_gamma_*:​LRP5_6*|​T1479_pho|​S1490_pho|​T1493_pho|​S1496_pho|​T1530_pho|​S1533_pho:​PRR*:​WNT*:​_beta_-Arrestin2*:​p120*|​S268_pho|​S269_pho@Endosome
8. LRP6@Cytoplasm → LRP6|​S1544_pho|​T1548_pho@Cytoplasm
9. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome → APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome
10. NFAT*|​pho|​pho@Nucleus → NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus
11. RCAN*|​pho@Cytoplasm → RCAN*|​pho|​pho@Cytoplasm
12. SNAI1@Nucleus → SNAI1|​pho@Nucleus