Protein NFAT* map

Identifiers
HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
HUGO:NFATC1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
HUGO:NFATC2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
HUGO:NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
HUGO:NFATC4
nuclear activator of activated T-cells 5, tonicity-responsive
HUGO:NFAT5
HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644
HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968
HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1
HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3
NF-ATP, NFAT1, NFATp
HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2
NF-ATC, NFAT2, NFATc
NFAT3
HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4
UNIIPROT:Q149934
nuclear factor of activated T-cells 5, tonicity-responsive
NFAT5
HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
 Innate Immunity  map  / MIRNA_TF_IMMUNOSTIMULATORY  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:11148124 PMID:8068174 PMID:10811803 PMID:11262396 PMID:10898494 PMID:19836308 PMID:11406367
nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1
REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1
nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3
REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NF-ATP, NFAT1, NFATp
REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2
NF-ATC, NFAT2, NFATc
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NFAT3
KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4
UNIIPROT:Q149934
nuclear factor of activated T-cells 5, tonicity-responsive
NFAT5
KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5
CASCADE:Fc_gamma_RIII
 NATURAL_KILLER  map
PMID:10089876, PMID:7650486, PMID:9973469
??Ca('2+)??activates Calmodulin 2 (??Calmodulin??)/ Protein phosphatase 3 (Calcineurin??) signal. Activated??Calcineurin??dephosphorylates Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2 (??NF-AT1(NFATC2)??).??
This signaling is activated downstream of CD16 in NK cells
PMID:7650486, PMID:9973469, PMID:9374532
NF-AT, migrates to the nucleus and activates transcription of cytokines TNF, ??GM-CSF??, IL-2, ??IL-4. Fas ligand (??FasL??)??and, possibly, IFNG.
NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype.
PMID:11274345
NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328.
PMID:11030334
NFAT5 activity is not regulated by phosphorylation but osmotic stress
PMID:11402342

NFAT*@Nucleus

References
te_re65:( Telomere Maintenance  map ) PMID:21790308 PMID:22381618 PMID:18754863 PMID:11274400 PMID:10606235 PMID:19846528 PMID:14673140 PMID:18222063 PMID:22723415

NFAT*@INNATE_IMMUNE_CELL_Cytosol

References
in_re1031( Innate Immunity  map ):
PMID:12907458
Bcl-3??? ???interacted with NF-??B p50,
both Bcl-3??? ???and p50??? ???were recruited to the TNF promoter,
BCL3??? ??? and??? ???p50??? ???NFkB recruitment to??? ???TNF ???promoter
prevents binding of??? ???p65/p50??? ???NFkB??? ???heterodimers
to??? ???TNF promotor and suppresses??? ???TNF ???expression
downstream of??? ???IL10.
PMID:17485448
Inhibition of??? ???NFkB signaling downstream of??? ???ABIN3??? ???
inhibits expression of??? ???IL8,??? ???IL6,??? ???TNF,??? ???IL12.
PMID:15465827
BCL3 forms complex with HDAC1 and
repression of the TNF promoter by BCL3
requires Histone Deacetylase Activity.
BCL3 inhibits expression of TNF.
PMID:11875494
HMOX1 (HO1) mediates IL-10-induced suppression of TNF production.
PMID:16878026, PMID:14660645, PMID:15644117, PMID:10952726
Increased TNF expression downstream of HMGB1 is regulated via MYD88 and probably NFkB.
PMID:10754326
Human TNF-alpha gene has binding sites for NF-kappa B. By transient transfection,
NF-kappa B p65 and p50 synergistically activated the TNF-alpha promoter.
Although both the kappa B1 and kappa B3 sites bound transcriptionally active NF-kappa B p50/p65 heterodimers, only the kappa B1 site contributed to down-regulation by NF-kappa B p50 homodimers.
PMID:17404308
CSF1 downregulates TNF, IL-23p19, IL-12p40 expression probably via induction of acomulation of p50 homodimer and inhibition of p65/p50 NF-kB signaling.
CSF2 upregulates expression of TNF, and have positive influence on IL12p70 (p40+p35), IL23 (p40+p19) expression, probably via induction rapid IkBa degradetion, RELA nuclear translocation and formation p65/p50 heterodimers provided induction of NFkB signaling.
PMID:7594497
TGFB1 and IL10 dowregulate expression of TNF.
PMID:23390297
MIF inhitits expression of M1 markers such as TNF.

NFAT*|​pho@Cytoplasm

References
su_mpk1_mpk1_re169( Survival  map ):
JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation.
PMID:11274345

NFAT*@Cytoplasm

References
su_mpk1_mpk1_re169( Survival  map ):
JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation.
PMID:11274345

NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm

References
s_wnc2_re59( Survival  map ):
PMID:10788511, PMID:10094050, PMID:9585406
For a more detailed mechanism see CRM1 in map Nucleus_MTOR

NFAT*|​pho|​pho@Nucleus

References
s_wnc2_re56( Survival  map ):
DYRK1A/B primes NFAT in the nucleus, DYRK2 in the cytosol
PMID:16511445
s_wnc2_re58:( Survival  map ) PMID:16511445, PMID:15121840

NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus

References
s_wnc2_re58:( Survival  map ) PMID:16511445, PMID:15121840
s_wnc2_re59( Survival  map ):
PMID:10788511, PMID:10094050, PMID:9585406
For a more detailed mechanism see CRM1 in map Nucleus_MTOR

NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm

References
s_wnc2_re72( Survival  map ):
Where exactly MDM2 ubiquitinates NFAT is not known and also not known if it is in the cytosol or nucleus.
PMID:16307918

NFAT*|​emp|​S289_pho|​S272_pho@Nucleus

References
s_wnc2_re85( Survival  map ):
S272 and S89 are PKA sites in NFAT3
PMID:10611249

Modifications:
In compartment: Cytoplasm
  1. NFAT*@Cytoplasm map
  2. NFAT*|​pho@Cytoplasm map
  3. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map
  4. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NFAT*@INNATE_IMMUNE_CELL_Cytosol map
  2. NFAT*|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. NFAT*@Nucleus map
  2. NFAT*|​pho|​pho@Nucleus map
  3. NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map
  4. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus map
In compartment: T_cell
  1. NFAT*@T_cell map
  2. NFAT*|​pho@T_cell map
Participates in complexes:
In compartment: Cytoplasm
  1. 14-3-3*:​NFAT*|​emp|​S289_pho|​S272_pho@Cytoplasm map
  2. HOMER3:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map
  3. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  4. (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  5. Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm map
  6. Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm map
  7. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  8. CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm map
  9. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  10. CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  11. CSE1L:​Ca2+:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
In compartment: Nucleus
  1. NF-_kappa_B:​NFAT*@Nucleus map
  2. AP-1_ARRE binding sites*:​NFAT*@Nucleus map
  3. CNA*:​CNB*:​NFAT*@Nucleus map
  4. GATA binding site*:​GATA*:​NFAT*@Nucleus map
  5. MEF2*:​NFAT*:​promoter binding site*@Nucleus map
  6. ERE:​ER_alpha_*:​FOXA*:​NFAT*@Nucleus map
  7. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map
  8. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  9. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map
  10. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. NFAT*|​pho@T_cell map → map NFAT*@T_cell map
  2. rNFAT*@T_cell map → map NFAT*@T_cell map
  3. NFAT*@T_cell map → map NFAT*|​pho@T_cell map
  4. NFAT*|​pho@INNATE_IMMUNE_CELL_Cytosol map → map NFAT*@INNATE_IMMUNE_CELL_Cytosol map
  5. rNFAT*@INNATE_IMMUNE_CELL_Cytosol map → map NFAT*@INNATE_IMMUNE_CELL_Cytosol map
  6. NFAT*@Cytoplasm map → map NFAT*|​pho@Cytoplasm map
  7. NFAT*@Cytoplasm map → map NFAT*@Nucleus map
  8. (PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map + NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map → map (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  9. (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map → map (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  10. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map → map KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  11. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm map + NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map → map Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm map
  12. Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm map → map Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm map
  13. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map → map Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  14. Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm map + KPNB1@Cytoplasm map + Tubulin-_alpha_*@Cytoplasm map + TNPO1@Cytoplasm map → map Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  15. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map + KPNB1@Cytoplasm map + Tubulin-_alpha_*@Cytoplasm map + TNPO1@Cytoplasm map → map KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  16. CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm map → map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map + IQGAP*@Cytoplasm map + DYRK*@Cytoplasm map + CK1_epsilon_*@Cytoplasm map + rNRON@Cytoplasm map + GSK3*@Cytoplasm map
  17. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + rNRON@Cytoplasm map + CSE1L@Cytoplasm map → map CSE1L:​Ca2+:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  18. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + CSE1L@Cytoplasm map + rNRON@Cytoplasm map → map CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  19. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map + HOMER3@Cytoplasm map → map HOMER3:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map
  20. NFAT*@Nucleus map → map NFAT*|​pho|​pho@Nucleus map
  21. NFAT*|​pho|​pho@Nucleus map → map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus map
  22. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Nucleus map → map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map
  23. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map → map CK1_epsilon_*:​DYRK*:​GSK3*:​IQGAP*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​NRON@Cytoplasm map
  24. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map → map NFAT*@Nucleus map + Tubulin-_alpha_*@Nucleus map + Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Nucleus map + KPNB1@Nucleus map
  25. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map → map NFAT1*@Cytoplasm map
  26. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm map → map degraded
  27. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map → map NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm map
  28. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map → map (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  29. NFAT*@Nucleus map → map NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map
  30. NFAT*|​emp|​S289_pho|​S272_pho@Nucleus map + 14-3-3*@Nucleus map → map su_wnc1_s_wnc2_s319
  31. su_wnc1_s_wnc2_s319 → map 14-3-3*:​NFAT*|​emp|​S289_pho|​S272_pho@Cytoplasm map
  32. estrogen@Nucleus map + ER_alpha_*@Nucleus map + gERE@Nucleus map + NFAT*@Nucleus map + FOXA*@Nucleus map → map ERE:​ER_alpha_*:​FOXA*:​NFAT*@Nucleus map
  33. NFAT3*|​S676_pho@Nucleus map → map NFAT*@Nucleus map
  34. NFAT1*|​unk|​unk@Nucleus map → map NFAT*@Nucleus map
  35. NFAT1*|​gly@Nucleus map → map NFAT*@Nucleus map
  36. CNA*:​CNB*:​NFAT*@Nucleus map → map CNA*:​CNB*@Nucleus map + NFAT*@Nucleus map
  37. CNA*:​CNB*:​NFAT*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map → map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map
  38. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*@Nucleus map → map CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map
  39. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map → map AP-1_ARRE binding sites*:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map
  40. gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map + NFAT*@Nucleus map → map AP-1_ARRE binding sites*:​NFAT*@Nucleus map
  41. gNF-_kappa_B@Nucleus map + NFAT*@Nucleus map → map NF-_kappa_B:​NFAT*@Nucleus map
  42. NFAT*@Nucleus map + GATA*@Nucleus map + gGATA binding site*@Nucleus map → map GATA binding site*:​GATA*:​NFAT*@Nucleus map
  43. NFAT*@Nucleus map + MEF2*@Nucleus map + gpromoter binding site*@Nucleus map → map MEF2*:​NFAT*:​promoter binding site*@Nucleus map
As Catalyser:
  1. gIL2@T_cell map → map rIL2@T_cell map
  2. gDTX1@T_cell map → map rDTX1@T_cell map
  3. gPDCD1@T_cell map → map rPDCD1@T_cell map
  4. gTNFRSF18@T_cell map → map rTNFRSF18@T_cell map
  5. gICOS@T_cell map → map rICOS@T_cell map
  6. gTNF@INNATE_IMMUNE_CELL_Cytosol map → map rTNF@INNATE_IMMUNE_CELL_Cytosol map
  7. gIL2@INNATE_IMMUNE_CELL_Cytosol map → map rIL2@INNATE_IMMUNE_CELL_Cytosol map
  8. gCSF2@INNATE_IMMUNE_CELL_Cytosol map → map rCSF2@INNATE_IMMUNE_CELL_Cytosol map
  9. gIL4@INNATE_IMMUNE_CELL_Cytosol map → map rIL4@INNATE_IMMUNE_CELL_Cytosol map
  10. gIFNG@INNATE_IMMUNE_CELL_Cytosol map → map rIFNG@INNATE_IMMUNE_CELL_Cytosol map
  11. gFASL*@INNATE_IMMUNE_CELL_Cytosol map → map rFASL*@INNATE_IMMUNE_CELL_Cytosol map
  12. gGPC6@Nucleus map → map rGPC6@Nucleus map
  13. CNA*:​CNB*:​ERK2*:​MEK1*:​NFAT*|​pho@Nucleus map + gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map → map AP-1_ARRE binding sites*:​NFAT*@Nucleus map + CNA*:​CNB*@Nucleus map + ERK2*@Nucleus map + MEK1*@Nucleus map
  14. gTERT@Nucleus map → map rTERT@Nucleus map