Identifiers
NAME:14-3-3*:BAD
References
s_akt1_re125:( Survival ) PMID:10949026
Identifiers
NAME:14-3-3*:BAD
References
s_akt1_re126:( Survival ) PMID:10949026
Identifiers
NAME:14-3-3*:BAD
Identifiers
NAME:14-3-3*:BAD
References
s_akt1_re127:( Survival ) PMID:10949026
Identifiers
NAME:14-3-3*:BAD
References
s_wnc2_re26:( Survival ) PMID:15036616, PMID:14741051
Identifiers
NAME:14-3-3*:BAD
References
s_wnc2_re26:( Survival ) PMID:15036616, PMID:14741051
s_wnc2_re30:( Survival ) PMID:22088220
Identifiers
NAME:14-3-3*:BAD
Identifiers
NAME:14-3-3*:BAD
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds to 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)
+ 14-3-3*@Cytosol → 14-3-3*:BAD|pho@Cytosol
→ 14-3-3*:BAD|S112_pho|S136_pho@Mitochondria
→ 14-3-3*:BAD|S112_pho|S136_pho|S155_pho@Mitochondria
→ 14-3-3*:BAD|S112_pho|S136_pho|S155_pho@Mitochondria + BCL2-XL*@Mitochondria
→ 14-3-3*:BAD|S112_pho|S136_pho|S155_pho@Cytoplasm
→ 14-3-3*:BAD|pho|pho@Cytoplasm
→ Survival@Mitochondria
→ 14-3-3*:BAD|pho|pho|pho@Cytoplasm
→ BAD|pho|pho@Cytoplasm + 14-3-3*@Cytoplasm
→ 14-3-3*:BAD|pho|pho|pho@Mitochondria