cleaved~AIFM1*

Protein cleaved~AIFM1*

Identifiers
apoptosis-inducing factor, mitochondrion-associated, 1
HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831

Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DNA_DAMAGE_RESPONSE
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / NECROPTOSIS
Regulated Cell Death / PARTHANATOS

References
PMID:21887410

cleaved~AIFM1*@Mitochondrial intermembrane space

References
rc_re723( Regulated Cell Death ):
PMID:15775970
AIF as an inner membrane protein that is cleaved and released into the intermembrane space upon apoptosis induction
PMID:15590628
calpain 1 mediated processing
PMID:15933737
cathepsins and calpain 1
PMID:11278689
flavin not necessary for apoptotic function
rc_re731( Regulated Cell Death ):
cleavage of AIF
rc_re4( Regulated Cell Death ):
PMID:8879205
release of AIF is blocked by BCL2 overexpression
but data supporting direct involvment of MOMP not found in the literature

cleaved~AIFM1*|ubi@Cytosol

References
rc_re734( Regulated Cell Death ):
PMID:17967870
in HEK293

cleaved~AIFM1*@Nucleus

References
rc_re724:( Regulated Cell Death ) PMID:17116881
rc_re1224( Regulated Cell Death ):
PMID:14716299
in Jurkat, interaction upon apoptosis induction by staurosporin or serum withdrawal
in Hela, colocalization in the nucleus

cleaved~AIFM1*@Mitochondrial inner membrane

cleaved~AIFM1*@Cytosol

Modifications:
In compartment: Cytosol

cleaved~AIFM1*@Cytosol
cleaved~AIFM1*|ubi@Cytosol

In compartment: Mitochondrial inner membrane

cleaved~AIFM1*@Mitochondrial inner membrane

In compartment: Mitochondrial intermembrane space

cleaved~AIFM1*@Mitochondrial intermembrane space

In compartment: Nucleus

cleaved~AIFM1*@Nucleus

Participates in complexes:
In compartment: Nucleus

PPIA:cleaved~AIFM1*@Nucleus

Participates in reactions:
As Reactant or Product:

As Catalyser:

DNA~integrity@Nucleus → DNA~fragmentation@Nucleus