Protein VDAC*
Identifiers
voltage-dependent anion channel 1
HUGO:VDAC1 HGNC:12669 ENTREZ:7416 UNIPROT:P21796
voltage-dependent anion channel 2
HUGO:VDAC2 HGNC:12672 ENTREZ:7417 UNIPROT:P45880
voltage-dependent anion channel 3
HUGO:VDAC3 HGNC:12674 ENTREZ:7419 UNIPROT:Q9Y277
Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death
/ APOPTOSIS
Regulated Cell Death
/ DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death
/ MOMP_REGULATION
Regulated Cell Death
/ MITOCHONDRIAL_PERMEABILITY_TRANSITION
Regulated Cell Death
/ NECROPTOSIS
References
PMID:21887410
PMID:18309324
PMID:17568748
VDAC*@Mitochondrial inner membrane
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death
/ APOPTOSIS
Regulated Cell Death
/ DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death
/ MOMP_REGULATION
Regulated Cell Death
/ NECROPTOSIS
References
PMID:17568748
rc_re726:( Regulated Cell Death
) reactionType:is.a
VDAC*@Mitochondria
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death
/ APOPTOSIS
Regulated Cell Death
/ DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death
/ MOMP_REGULATION
Regulated Cell Death
/ NECROPTOSIS
References
PMID:17568748
rc_re1667:( Regulated Cell Death
) PMID:21887410
Modifications:
In compartment: Cytosol
- VDAC*@Cytosol
In compartment: Mitochondria
- VDAC*@Mitochondria
In compartment: Mitochondria inner membrane
- VDAC*@Mitochondria inner membrane
In compartment: Mitochondrial inner membrane
- VDAC*@Mitochondrial inner membrane
Participates in complexes:
In compartment: Endopasmic Reticulum
- BiP*:Ca2+:Grp75*:ITPR*:SIGMAR1:VDAC*@Endopasmic Reticulum
In compartment: Mitochondrial inner membrane
- (ANT*:CK*:HK*:PPID:TSPO:VDAC*)|active@Mitochondrial inner membrane
Participates in reactions:
As Reactant or Product:- VDAC3@Mitochondrial inner membrane
→
VDAC*@Mitochondrial inner membrane
- VDAC1@Mitochondrial inner membrane
→
VDAC*@Mitochondrial inner membrane
- (ANT*:CK*:HK*:PPID:TSPO:VDAC*)|active@Mitochondrial inner membrane
→
(ANT*:CK*:HK*:PPID:TSPO:VDAC*)|active@Mitochondrial inner membrane
- (ANT*:CK*:HK*:PPID:TSPO:VDAC*)|active@Mitochondrial inner membrane
→
MOMP@Mitochondrial inner membrane
- VDAC*@Mitochondria
→
degraded
- Grp75*@Endopasmic Reticulum
+ BiP*:SIGMAR1@Endopasmic Reticulum
+ Ca2+@Endopasmic Reticulum
+ ITPR*@Cytosol
+ VDAC*@Cytosol
→
BiP*:Ca2+:Grp75*:ITPR*:SIGMAR1:VDAC*@Endopasmic Reticulum
- VDAC1@Mitochondria inner membrane
→
VDAC*@Mitochondria inner membrane
- VDAC2@Mitochondria inner membrane
→
VDAC*@Mitochondria inner membrane
- VDAC3@Mitochondria inner membrane
→
VDAC*@Mitochondria inner membrane
- VDAC*@Mitochondria
+ ANT*@Mitochondrial inner membrane
+ PPID@Mitochondria
+ CK*@Mitochondria
+ HK*@Cytosol
+ TSPO@Mitochondria
→
(ANT*:CK*:HK*:PPID:TSPO:VDAC*)|active@Mitochondrial inner membrane
- (ANT*:CK*:HK*:PPID:TSPO:VDAC*)|active@Mitochondrial inner membrane
→
ROS Production@Cytosol
- VDAC2@Mitochondrial inner membrane
→
VDAC*@Mitochondrial inner membrane
As Catalyser:- ATP@Mitochondrial inner membrane
+ ADP@Cytosol
→
ATP@Cytosol
+ ADP@Mitochondrial inner membrane
- cleaved~AIFM1*@Mitochondrial inner membrane
→
cleaved~AIFM1*@Cytosol
- Ca2+@Endopasmic Reticulum
→
BiP*:Ca2+:Grp75*:ITPR*:SIGMAR1:VDAC*@Endopasmic Reticulum
- succinate@Mitochondrial intermembrane space
→
succinate@Cytosol