Identifiers
apoptosis-inducing factor, mitochondrion-associated, 1
HUGO:AIFM1 HGNC:8768 ENTREZ:9131 UNIPROT:O95831

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 Regulated Cell Death   / RCD_GENES 
 Regulated Cell Death   / PARTHANATOS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 

References
synonym:AIF
NOTE: * means carbonylated
PMID:24684389
There is a small pool of AIF on the outer mitochondrial membrane (cytosolic side)

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 Regulated Cell Death   / RCD_GENES 

References
rc_re732:( Regulated Cell Death  ) reactionType:is.a
rc_re723( Regulated Cell Death  ):
PMID:15775970
AIF as an inner membrane protein that is cleaved and released into the intermembrane space upon apoptosis induction
PMID:15590628
calpain 1 mediated processing
PMID:15933737
cathepsins and calpain 1
PMID:11278689
flavin not necessary for apoptotic function
rc_re730( Regulated Cell Death  ):
PMID:20043986
in isolated mitochondria, Ca2+-dependent and ROS-mediated carbonylation of AIF.
carbonylated AIF as a prefered substrate for calpains

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 Regulated Cell Death   / RCD_GENES 

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 Regulated Cell Death   / RCD_GENES 

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 Regulated Cell Death   / RCD_GENES 

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 Regulated Cell Death   / RCD_GENES 

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE 
 Regulated Cell Death   / RCD_GENES 

1. AIFM1@Cytosol

1. AIFM1|​don@Mitochondria
2. AIFM1|​don@Mitochondria

1. AIFM1@Mitochondrial inner membrane
2. AIFM1|​don@Mitochondrial inner membrane

1. AIFM1@Nucleus

1. AIFM1:​FAD@Mitochondrial inner membrane

1. AIFM1:​PAR Polymer@Nucleus

1. AIFM1|​don@Mitochondrial inner membrane → cleaved~AIFM1*@Mitochondrial inner membrane
2. rAIFM1@Nucleus → AIFM1@Cytosol
3. AIFM1|​don@Mitochondria → AIFM1@Nucleus
4. AIFM1|​don@Mitochondria → AIFM1@Nucleus
5. AIFM1@Nucleus + PAR Polymer@Nucleus → AIFM1:​PAR Polymer@Nucleus
6. AIFM1:​PAR Polymer@Nucleus → DNA~fragmentation@Nucleus
7. AIFM1:​PAR Polymer@Nucleus → Chromatin condensation@Nucleus
8. AIFM1:​PAR Polymer@Nucleus → Cell death@Cytosol
9. AIFM1@Mitochondrial inner membrane → cleaved~AIFM1*@Mitochondrial intermembrane space
10. AIFM1@Mitochondrial inner membrane + FAD@Mitochondrial inner membrane → AIFM1:​FAD@Mitochondrial inner membrane
11. AIFM1@Mitochondrial inner membrane + ROS@Mitochondrial inner membrane → AIFM1|​don@Mitochondrial inner membrane
12. AIFM1|​don@Mitochondrial inner membrane → cleaved~AIFM1*@Mitochondrial intermembrane space
13. AIFM1|​don@Mitochondrial inner membrane → AIFM1@Mitochondrial inner membrane

1. degraded + NDUFS8@Mitochondrial inner membrane + MT-ND5@Mitochondrial inner membrane + MT-ND4@Mitochondrial inner membrane + MT-ND4L@Mitochondrial inner membrane + MT-ND3@Mitochondrial inner membrane + MT-ND2@Mitochondrial inner membrane + MT-ND1@Mitochondrial inner membrane + MT-ND6@Mitochondrial inner membrane → FMN:​MT-ND1:​MT-ND2:​MT-ND3:​MT-ND4:​MT-ND4L:​MT-ND5:​MT-ND6:​NDUFA1:​NDUFA10:​NDUFA11:​NDUFA12:​NDUFA13:​NDUFA2:​NDUFA3:​NDUFA4:​NDUFA5:​NDUFA6:​NDUFA7:​NDUFA8:​NDUFA9:​NDUFAB1:​NDUFB1:​NDUFB10:​NDUFB11:​NDUFB2:​NDUFB3:​NDUFB4:​NDUFB5:​NDUFB6:​NDUFB7:​NDUFB8:​NDUFB9:​NDUFC1:​NDUFC2:​NDUFS1|​[2Fe-2S],[4Fe-4S],[4Fe-4S]:​NDUFS2:​NDUFS3:​NDUFS4:​NDUFS5:​NDUFS6:​NDUFS7|​[4Fe-4S]:​NDUFS8|​[4Fe-4S],[4Fe-4S]:​NDUFV1|​[4Fe-4S]:​NDUFV2|​[2Fe-2S]:​NDUFV3@Mitochondrial inner membrane