Identifiers
NAME:Ca2+:DAG:PKC*
References
su_mpk1_mpk1_re263( Survival ):
Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity.
PMID:15567848
su_mpk1_mpk1_re25( Survival ):
Grb2 is recruited to the plasma membrane by activated RTKs.
FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation.
PKC may cause phosphorylation of EGFR leading to a decrease in its activity.
PMID:17496910 PMID:15567848 PMID:11447289 PMID:6321473
su_mpk1_mpk1_re40( Survival ):
In addition to Grb2/SOS PLCG and SRC are also recruited to activated PTKRs at the PM.
Activation of the TCR results in tyrosine phosphorylation of the ?? chain of the receptor by Src family kinases and the resulting phosphotyrosines serve to recruit ZAP-70 (not modelled) that in turn phosphorylates the scaffold protein LAT (not modelled) at multiple sites.
PMID:19615955 PMID:16488589 PMID:15567848
su_mpk1_mpk1_re283( Survival ):
PKCalpha directly phosphorylates and activates Raf-1.
PMID:8321321