Reaction state_transition rc_re334 map

AMP:​PKA_R*:​PRKAA*:​PRKAG*@Cytosol map → AMP:​PKA_R*:​PRKAA*|​T172_pho:​PRKAG*@Cytosol map

Reaction regulators:
Boolean_logic_gate_and
  1. CAMKK2@Cytosol map and
Boolean_logic_gate_or
  1. SESN1@Cytosol map and SESN2@Cytosol map
Catalysis
  1. Ca2+@Cytosol map
  2. SESN1@Cytosol map
  3. SESN2@Cytosol map
  4. CAMKK2@Cytosol map
  5. TAK1*|​T187_pho@TNFRSF1 Receptor Complex map
  6. STK11|​K48_unk|​T366_unk|​active@Cytosol map


References
PMID:15509864
review
PMID:16054095
by CAMKK2
PMID:16054096
PMID:17244528
by calcium via CAMKK2 and AMPK
PMID:15980064
by CAMKK
PMID:18692468
propose that SESN2 promotes AMPK autophosphorylation, thus increasing TSC1/2 activity.
PMID:19197243
in RPE1-hTERT mouse inner medullary collecting duct cells, in MEFs, in MCF10A, by TAK1, upon TRAIL exposure
in MCF10A upon Ca2+ by CAMKK2
High Calcium lvl activate CAMKK2 enzyme and leads to AMPK activation
PMID:19037093PMID:17244528
PMID:20484410