Identifiers
HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C HUGO:TUBA3D HGNC:24071 ENTREZ:113457 GENECARDS:TUBA3D HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8
tubulin, alpha 1a
HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A
SwissProt: Q71U36
tubulin, alpha 1b
HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B
SwissProt: P68363
tubulin, alpha 1c
HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C
SwissProt: Q9BQE3
tubulin, alpha 3c
HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C
SwissProt: Q13748
tubulin, alpha 3d
HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D
tubulin, alpha 3e
HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E
SwissProt: Q6PEY2
tubulin, alpha 4a
HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A
SwissProt: P68366
tubulin, alpha 8
HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8
SwissProt: Q9NY65
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / WNT_NON_CANONICAL
References
PMID:18287025
REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A
SwissProt:Q71U36
REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B
SwissProt:P68363
REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C
SwissProt:Q9BQE3
tubulin, alpha 3c
REACTOME:154750 KEGG:7278 WIKI:TUBA3C
SwissProt: Q13748
REACTOME:154750 KEGG:113457 WIKI:TUBA3D
tubulin, alpha 3e
WIKI:TUBA3E
SwissProt:Q6PEY2
REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A
SwissProt: P68366
KEGG:51807 WIKI:TUBA8
SwissProt:Q9NY65
NATURAL_KILLER
References
s_wnc2_re44( Survival ):
Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT.
PMID:21278340
TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex
PMID:21709260
+ PXN|pho@T_cell → PXN:TUBGCP2:TUBGCP3:TUBGCP4:TUBGCP5:TUBGCP6:Tubulin-_alpha_*:Tubulin-_beta_*:Tubulin-_gamma_*@T_cell
→ Centrosome polarization@T_cell
+ PXN@INNATE_IMMUNE_CELL_Cytosol → PXN:TUBGCP2:TUBGCP3:TUBGCP4:TUBGCP5:TUBGCP6:Tubulin-_alpha_*:Tubulin-_beta_*:Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol
→ MTOC_polarization@INNATE_IMMUNE_CELL_Cytosol
→ KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:Tubulin-_alpha_*@Nucleus
→ Ca2+:Calmodulin*:KPNB1:NFAT*:PPP3CB:PPP3R*:Tubulin-_alpha_*@Nucleus
+ KPNB1@Cytoplasm + Tubulin-_alpha_*@Cytoplasm + TNPO1@Cytoplasm → Ca2+:Calmodulin*:KPNB1:NFAT*:PPP3CB:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
+ KPNB1@Cytoplasm + Tubulin-_alpha_*@Cytoplasm + TNPO1@Cytoplasm → KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
+ LRRK2@Cytoplasm + rNRON@Cytoplasm + CSE1L@Cytoplasm → CSE1L:Ca2+:Calmodulin*:KPNB1:LRRK2:NFAT*:NRON:PPP3CB:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
+ LRRK2@Cytoplasm + CSE1L@Cytoplasm + rNRON@Cytoplasm → CSE1L:KPNB1:LRRK2:NFAT*:NRON:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_*@Cytoplasm
→ NFAT*@Nucleus + Tubulin-_alpha_*@Nucleus + Ca2+:Calmodulin*:PPP3CB:PPP3R*@Nucleus + KPNB1@Nucleus