Identifiers
HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 GENECARDS:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 GENECARDS:CALM3
HUGO:CALM1 HUGO:CALM2 HUGO:CALM3
calmodulin 1 (phosphorylase kinase, delta)
CALML2
HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3
calmodulin 2 (phosphorylase kinase, delta)
HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3
calmodulin 3 (phosphorylase kinase, delta)
HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_NON_CANONICAL 

References
PMID:10089876 PMID:7650486 PMID:9973469
calmodulin 1 (phosphorylase kinase, delta)
CALML2
REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 REACTOME:51306 KEGG:805 WIKI:CALM2 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3
calmodulin 2 (phosphorylase kinase, delta)
REACTOME:51306 KEGG:805 WIKI:CALM2 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3
calmodulin 3 (phosphorylase kinase, delta)
REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 REACTOME:51306 KEGG:805 WIKI:CALM2
CASCADE:Fc_gamma_RIII
 NATURAL_KILLER 
??Ca('2+)??activates Calmodulin 2 (??Calmodulin??)/ Protein phosphatase 3 (Calcineurin??) signal. Activated??Calcineurin??dephosphorylates Nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 2 (??NF-AT1(NFATC2)??).??
This signaling is activated downstream of CD16 in NK cells.

References
mo_re204:( motility  ) PMID:23572150

References
s_wnc1_re160:( Survival  ) PMID:19725819

1. Calmodulin*@Cytoplasm

1. Calmodulin*@Cytosol

1. Calmodulin*@INNATE_IMMUNE_CELL_Cytosol

1. Calmodulin*@T_cell

1. Ca2+:​Calmodulin*@Cytoplasm
2. Ca2+:​Calmodulin*@Cytoplasm
3. CAMK2*:​Ca2+:​Calmodulin*@Cytoplasm
4. CAMK2*:​Ca2+:​Calmodulin*@Cytoplasm
5. Ca2+:​Calmodulin*:​PPP3R*@Cytoplasm
6. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm
7. Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm
8. Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm
9. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
10. CSE1L:​Ca2+:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm

1. Ca2+:​Calmodulin*@Cytosol
2. CAMK2*:​Ca2+:​Calmodulin*@Cytosol

1. Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol
2. CNA*:​CNB*:​Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol

1. Ca2+:​Calmodulin*@Nucleus
2. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Nucleus
3. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus

1. Ca2+:​Calmodulin*@T_cell
2. CNA*:​CNB*:​Ca2+:​Calmodulin*@T_cell

1. Ca2+@T_cell + Calmodulin*@T_cell → Ca2+:​Calmodulin*@T_cell
2. Ca2+:​Calmodulin*@T_cell + CNA*:​CNB*@T_cell → CNA*:​CNB*:​Ca2+:​Calmodulin*@T_cell
3. Ca2+@INNATE_IMMUNE_CELL_Cytosol + Calmodulin*@INNATE_IMMUNE_CELL_Cytosol → Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol
4. Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol + CNA*:​CNB*@INNATE_IMMUNE_CELL_Cytosol → CNA*:​CNB*:​Ca2+:​Calmodulin*@INNATE_IMMUNE_CELL_Cytosol
5. Ca2+@Cytosol + Calmodulin*@Cytosol → Ca2+:​Calmodulin*@Cytosol
6. CAMK2*@Cytosol + Ca2+:​Calmodulin*@Cytosol → CAMK2*:​Ca2+:​Calmodulin*@Cytosol
7. CAMK2*:​Ca2+:​Calmodulin*@Cytosol → EMT & motility@Cytosol
8. Calmodulin*@Cytoplasm + Ca2+@Cytoplasm → Ca2+:​Calmodulin*@Cytoplasm
9. CAMK2*@Cytoplasm + Ca2+:​Calmodulin*@Cytoplasm → CAMK2*:​Ca2+:​Calmodulin*@Cytoplasm
10. CAMK2*:​Ca2+:​Calmodulin*@Cytoplasm → MAPK pathway@Cytoplasm
11. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm + NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm → Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm
12. Ca2+:​Calmodulin*:​NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB:​PPP3R*@Cytoplasm → Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm
13. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm → Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus
14. Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm + KPNB1@Cytoplasm + Tubulin-_alpha_*@Cytoplasm + TNPO1@Cytoplasm → Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
15. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm + LRRK2@Cytoplasm + rNRON@Cytoplasm + CSE1L@Cytoplasm → CSE1L:​Ca2+:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm
16. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm → Ca2+:​Calmodulin*:​PPP3R*@Cytoplasm
17. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus → NFAT*@Nucleus + Tubulin-_alpha_*@Nucleus + Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Nucleus + KPNB1@Nucleus
18. PPP3CB:​PPP3R*@Cytoplasm + Ca2+:​Calmodulin*@Cytoplasm → Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm

1. NFAT*|​pho@T_cell → NFAT*@T_cell
2. CAMK2*@T_cell → CAMK2*|​pho|​active@T_cell
3. BCL10|​pho@T_cell → BCL10@T_cell
4. NFAT*|​pho@INNATE_IMMUNE_CELL_Cytosol → NFAT*@INNATE_IMMUNE_CELL_Cytosol
5. gNFAT*@INNATE_IMMUNE_CELL_Cytosol → rNFAT*@INNATE_IMMUNE_CELL_Cytosol
6. GSK3??*@Cytosol → GSK3??*|​Ser9_pho@Cytosol
7. gE-cadherin*@Nucleus → rE-cadherin*@Nucleus
8. Snail*|​pho@Nucleus → Snail*@Nucleus
9. AKT1@Cytosol → AKT1|​ser473_pho|​active@Cytosol
10. AKT1@Cytoplasm → AKT1|​pho|​active@Cytoplasm
11. 14-3-3*:​BAD|​pho|​pho|​pho@Cytoplasm → 14-3-3*:​BAD|​pho|​pho@Cytoplasm
12. Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Cytoplasm → Ca2+:​Calmodulin*:​PPP3R*@Cytoplasm
13. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm → TAB1:​TAB2:​TAK1*|​emp@Cytoplasm
14. MEF2*|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm → MEF2*@Cytoplasm
15. estrogen@Nucleus + ER_alpha_*@Nucleus + gERE@Nucleus + NFAT*@Nucleus + FOXA*@Nucleus → ERE:​ER_alpha_*:​FOXA*:​NFAT*@Nucleus