Reaction state_transition rc_re723 map

AIFM1@Mitochondrial inner membrane map → cleaved~AIFM1*@Mitochondrial intermembrane space map

Reaction regulators:
Boolean_logic_gate_or
  1. CTSL*@Mitochondrial intermembrane space map and CTSS@Mitochondrial intermembrane space map and CTSB@Mitochondrial intermembrane space map and CAPN1:​Ca2+@Mitochondrial intermembrane space map
Catalysis
  1. CTSB@Mitochondrial intermembrane space map
  2. CTSS@Mitochondrial intermembrane space map
  3. CTSL*@Mitochondrial intermembrane space map
  4. CAPN1:​Ca2+@Mitochondrial intermembrane space map


References
PMID:15775970
AIF as an inner membrane protein that is cleaved and released into the intermembrane space upon apoptosis induction
PMID:15590628
calpain 1 mediated processing
PMID:15933737
cathepsins and calpain 1
PMID:11278689
flavin not necessary for apoptotic function