Protein KPNB1 map

Identifiers
karyopherin (importin) beta 1
HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_NON_CANONICAL  map

KPNB1@Cytoplasm

References
s_wnc2_re44( Survival  map ):
Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT.
PMID:21278340
TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex
PMID:21709260

Modifications:
In compartment: Cytoplasm
  1. KPNB1@Cytoplasm map
In compartment: Nucleus
  1. KPNB1@Nucleus map
Participates in complexes:
In compartment: Cytoplasm
  1. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  2. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  3. CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  4. CSE1L:​Ca2+:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
In compartment: Nucleus
  1. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  2. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map → map KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  2. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map → map Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  3. Ca2+:​Calmodulin*:​NFAT*:​PPP3CB:​PPP3R*@Cytoplasm map + KPNB1@Cytoplasm map + Tubulin-_alpha_*@Cytoplasm map + TNPO1@Cytoplasm map → map Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  4. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map + KPNB1@Cytoplasm map + Tubulin-_alpha_*@Cytoplasm map + TNPO1@Cytoplasm map → map KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  5. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + rNRON@Cytoplasm map + CSE1L@Cytoplasm map → map CSE1L:​Ca2+:​Calmodulin*:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  6. KPNB1:​NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map + LRRK2@Cytoplasm map + CSE1L@Cytoplasm map + rNRON@Cytoplasm map → map CSE1L:​KPNB1:​LRRK2:​NFAT*:​NRON:​PPP3CB_sub_trunc_endsub_*:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map
  7. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map → map NFAT*@Nucleus map + Tubulin-_alpha_*@Nucleus map + Ca2+:​Calmodulin*:​PPP3CB:​PPP3R*@Nucleus map + KPNB1@Nucleus map
As Catalyser: