Identifiers
ring-box 1
HUGO:RBX1, HGNC:9928, ENTREZ:9978, UNIPROT:P62877
ring-box 1, E3 ubiquitin protein ligase
HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1
"ring-box 1"

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / S_PHASE_CHECKPOINT 
 Cell Cycle DNA Repair   / G2_M_CHECKPOINT 
 Cell Cycle DNA Repair   / NER 
 Cell Cycle DNA Repair   / FANCONI 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FAS_RESPONSE 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / TRAIL_RESPONSE 
 Regulated Cell Death   / FERROPTOSIS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / HEDGEHOG 
 Survival   / PI3K_AKT_MTOR 
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
PMID:15459660
For NER pathway:
PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249
For Fanconi pathway:
PMID:19686080, PMID:19622404, PMID:18931676
PMID:15340381
PMID:12820959
PMID:15688063

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / ANTIOXIDANT_RESPONSE 
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / FAS_RESPONSE 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / TRAIL_RESPONSE 

1. RBX1@Cytoplasm

1. RBX1@Cytosol

1. RBX1@Nucleus

1. CUL3:​KLHL*:​RBX1@Cytoplasm
2. CUL1:​RBX1:​RICTOR@Cytoplasm
3. CUL1:​RBX1:​RICTOR|​T1135_pho@Cytoplasm
4. CUL1:​FBW7*:​RBX1:​SKP1@Cytoplasm
5. CUL3:​DVL*:​KLHL*:​RBX1@Cytoplasm
6. ATROGIN-1*:​CUL1:​RBX1:​SKP1@Cytoplasm
7. CUL1:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm
8. CUL1:​RBX1:​SKP1:​_beta_TRCP*@Cytoplasm
9. CUL4*:​DCAF*:​FBW5*:​RBX1:​TSC2@Cytoplasm
10. CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm
11. CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​NEDD8:​PKD*:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_TRCP*@Cytoplasm
12. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm

1. CUL3:​RBX1@Cytosol
2. CUL3:​KEAP1:​RBX1@Cytosol
3. CUL1:​RBX1:​SKP1:​_beta_TRCP*@Cytosol
4. CUL4A:​DDB1:​RBX1:​_beta_TRCP*@Cytosol
5. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol
6. CISH:​CUL2:​RBX1:​TCEB1:​TCEB2:​TCEB3@Cytosol
7. 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol

1. CSA*:​CUL4*:​DDB1:​RBX1@Nucleus
2. CUL4*:​DDB1:​DDB2:​RBX1@Nucleus
3. CUL1:​RBX1:​SKP1:​SKP2:​_beta_TRCP*@Nucleus

1. _beta_TRCP*@Nucleus + SKP1@Nucleus + CUL1@Nucleus + RBX1@Nucleus + SKP2@Nucleus → CUL1:​RBX1:​SKP1:​SKP2:​_beta_TRCP*@Nucleus
2. RBX1@Nucleus + CUL4*@Nucleus + DDB1@Nucleus + CSA*@Nucleus → CSA*:​CUL4*:​DDB1:​RBX1@Nucleus
3. DDB2@Nucleus + RBX1@Nucleus + CUL4*@Nucleus + DDB1@Nucleus → CUL4*:​DDB1:​DDB2:​RBX1@Nucleus
4. CUL3:​RBX1@Cytosol + Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol → CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol
5. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol → Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol
6. RBX1@Cytosol + CUL3@Cytosol → CUL3:​RBX1@Cytosol
7. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol → rc_s6308
8. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol + CFLAR@Cytosol + RIPK1@Cytosol + RIPK3@Cytosol + MLKL@Cytosol → CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol + CUL3:​RBX1@Cytosol
9. HIF1A@Cytosol + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol → HIF1A|​P564_hyd@Cytosol + succinate@Cytosol + CO_sub_2_endsub_@Cytosol
10. CUL4*:​DCAF*:​FBW5*:​RBX1:​TSC2@Cytoplasm → Ubiquitination@Cytoplasm
11. CUL1:​RBX1:​RICTOR@Cytoplasm → CUL1:​RBX1:​RICTOR|​T1135_pho@Cytoplasm
12. CUL1:​RBX1:​RICTOR|​T1135_pho@Cytoplasm → RICTOR|​T1135_pho@Cytoplasm + CUL1@Cytoplasm + RBX1@Cytoplasm
13. E1*@Cytoplasm + RAD6*@Cytoplasm + NEDD8@Cytoplasm + CUL1:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm + FAF*@Cytoplasm → CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm
14. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm
15. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm → CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​NEDD8:​PKD*:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_TRCP*@Cytoplasm + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm
16. DVL*@Cytoplasm + CUL3:​KLHL*:​RBX1@Cytoplasm → CUL3:​DVL*:​KLHL*:​RBX1@Cytoplasm

1. TC-NER_DNA_st1*:​Transcription machine_br_(RNAPII)*@Nucleus → Transcription machine_br_(RNAPII)*@Nucleus + gTC-NER_DNA_st2*@Nucleus
2. FANCM|​pho@Nucleus → degraded
3. gGG-NER_DNA_st1*@Nucleus → gGG-NER_DNA_st2*@Nucleus
4. CyclinD*@Nucleus → degraded
5. CyclinE*@Nucleus → degraded
6. CDC25A@Nucleus → degraded
7. CDC25B@Nucleus → degraded
8. WEE1|​pho@Nucleus → degraded
9. EMI1*|​pho@Nucleus → degraded
10. DDIT4|​pho@Cytosol → DDIT4|​pho|​ubi@Cytosol
11. NFKBIA|​pho@Cytosol → NFKBIA|​pho|​ubi@Cytosol
12. BCL2@Cytosol → BCL2|​ubi@Cytosol
13. HIF1A|​P564_hyd@Cytosol → HIF1A|​ubi|​P564_hyd@Cytosol
14. IKK_beta_*@Cytosol → IKK_beta_*|​ubi@Cytosol
15. NFE2L2@Cytosol → NFE2L2|​ubi@Cytosol
16. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytosol → degraded
17. BimEL*@Cytosol → BimEL*|​ubi@Cytosol
18. BCL2L11|​ubi@Cytosol → BimEL*|​ubi@Cytosol
19. PHLPP*|​S869_pho|​S847_pho@Cytoplasm → PHLPP*|​S869_pho|​S847_pho|​ubi|​ubi@Cytoplasm
20. MTOR@Cytoplasm → MTOR|​Y631_ubi@Cytoplasm
21. SGK1@Cytoplasm → SGK1|​ubi@Cytoplasm
22. PDCD4|​S67_pho@Cytoplasm → PDCD4|​S67_pho|​ubi@Cytoplasm
23. GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho:​SUFU:​ULK3@Cytosol → GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho|​ubi|​ubi|​ubi|​ubi:​SUFU:​ULK3@Cytosol
24. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho:​SUFU:​ULK3@Cytosol → GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi:​SUFU:​ULK3@Cytosol
25. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol → GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol
26. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm
27. PPP3CB:​PPP3R*@Cytoplasm → PPP3CB|​ubi|​ubi|​ubi:​PPP3R*@Cytoplasm