Reaction state_transition rc_re387 map

HIF1A@Cytosol map + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map → HIF1A|​P564_hyd@Cytosol map + succinate@Cytosol map + CO_sub_2_endsub_@Cytosol map

Reaction regulators:
Boolean_logic_gate_and
  1. Fe2+:​PHD*@Cytosol map and OS9@Cytosol map
Catalysis
  1. OS9@Cytosol map
  2. Fe2+:​PHD*@Cytosol map
Inhibition
  1. fumarate@Cytosol map
  2. succinate@Cytosol map


References
PMID:12351678
identification of PHD2 as a HIF1A prolyl hydroxylase
PMID:15652751
inhibition of HIF1A prolyl hydroxylation by succinate and fumarate
PMID:15721254
in 293 cells, OS9 interacts with HIF1 and PHD and promotes HIF1A prolylhydroxylation and degradation