Protein CFLAR map

Identifiers
HUGO:CFLAR
CASP8 and FADD-like apoptosis regulator
HUGO:CFLAR HGNC:1876 ENTREZ:8837 UNIPROT:O15519

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
PMID:12215447 PMID:17462996
PMID:15760909
PMID:19838173
PMID:26972597
FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce

CFLAR@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

CFLAR|​pho@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
rc_re1146:( Regulated Cell Death  map ) PMID:16469705

CFLAR|​ubi@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
rc_re1542( Regulated Cell Death  map ):
PMID:16469705
JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L).
PMID:26972597
FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce

Modifications:
In compartment: Cytosol
  1. CFLAR@Cytosol map
  2. CFLAR|​pho@Cytosol map
  3. CFLAR|​ubi@Cytosol map
In compartment: T_cell
  1. CFLAR@T_cell map
Participates in complexes:
In compartment: Cytosol
  1. ATG3:​CFLAR@Cytosol map
  2. CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map
In compartment: Endosome
  1. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  2. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
Participates in reactions:
As Reactant or Product:
  1. CFLAR@T_cell map → map cFLIP_L*@T_cell map
  2. rCFLAR@Nucleus map → map CFLAR@Cytosol map
  3. CFLAR@Cytosol map → map CFLAR|​pho@Cytosol map
  4. CFLAR|​pho@Cytosol map → map degraded
  5. rc_s4026 + CFLAR@Cytosol map → map rc_s3884
  6. CFLAR@Cytosol map → map CFLAR|​ubi@Cytosol map
  7. CFLAR|​ubi@Cytosol map → map degraded
  8. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map + CFLAR@Cytosol map + RIPK1@Cytosol map + RIPK3@Cytosol map + MLKL@Cytosol map → map CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map + CUL3:​RBX1@Cytosol map
  9. CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
  10. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  11. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
  12. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
  13. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map ASK1*@Cytosol map
  14. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  15. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  16. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map Caspase8*|​ubi:​FLASH*@Cytosol map
  17. ATG3@Autopagosome map + CFLAR@Cytosol map → map ATG3:​CFLAR@Cytosol map
  18. rCFLAR@Nucleus map → map CFLAR@Cytosol map
As Catalyser: