Identifiers
Fanconi anemia, complementation group M
HUGO:FANCM, HGNC:23168, ENTREZ:57697, UNIPROT:Q8IYD8

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair   / S_PHASE_CHECKPOINT 
 Cell Cycle DNA Repair   / FANCONI 
 Cell Cycle DNA Repair   / NER 
 Cell Cycle DNA Repair   / TLS 

References
PMID:19686080, PMID:19622404, PMID:18931676, PMID:23444773
FANCM/FAAP24 is a sensor of ICL and recruiter of Fanconi core complex
PMID:19622404
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase
PMID:19282663, PMID:19622404
Link between Fanconi and NER
PMID:22615860
Fanconi and cross-linking agents
PMID:21948210
FA core complex regulates REV1 and activated TLS
PMID:22266823

References
ce_re194( Cell Cycle DNA Repair  ):
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
ce_re195( Cell Cycle DNA Repair  ):
FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156

References
ce_re14( Cell Cycle DNA Repair  ):
Link between Fanconi and NER
PMID:22615860
ce_re194( Cell Cycle DNA Repair  ):
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
ce_re199( Cell Cycle DNA Repair  ):
HCLK2*/FANCM/FAAP24/active ATR complex inhibit S-phase:
PMID:19282663, PMID:19622404, PMID:18995830
ce_re252( Cell Cycle DNA Repair  ):
Requirement for functional DNA polymerase eta in genome-wide repair by NER of UV-induced DNA damage during S phase:
PMID:20457011

1. FANCM@Nucleus
2. FANCM|​pho@Nucleus

1. FAAP24*:​FANCM@Nucleus
2. ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@Nucleus
3. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus
4. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​TOP3A@Nucleus

1. FAAP24*@Nucleus + FANCM@Nucleus → FAAP24*:​FANCM@Nucleus
2. FANCA|​pho:​FANCG|​S7_pho@Nucleus + FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF@Nucleus + FAAP24*:​FANCM@Nucleus + FAAP100*:​FANCB:​FANCL@Nucleus + BLM@Nucleus + HES1@Nucleus + FAAP20*@Nucleus → BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus
3. FANCM@Nucleus → FANCM|​pho@Nucleus
4. FANCM|​pho@Nucleus → degraded
5. HCLK2*@Nucleus + FAAP24*@Nucleus + FANCM@Nucleus + ATR|​pho|​active@Nucleus → ATR|​pho:​FAAP24*:​FANCM:​HCLK2*@Nucleus
6. BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1@Nucleus + TOP3A@Nucleus + RPA1:​RPA2:​RPA3@Nucleus → BLM:​FAAP100*:​FAAP20*:​FAAP24*:​FANCA|​pho:​FANCB:​FANCC:​FANCE|​S376_pho|​T346_pho:​FANCF:​FANCG|​S7_pho:​FANCL:​FANCM:​HES1:​TOP3A@Nucleus

1. S phase@Nucleus → G2 phase@Nucleus
2. G2 phase@Nucleus → M phase@Nucleus
3. gTC-NER_DNA_st2*@Nucleus → gTC-NER_GG-NER_DNA_st3*@Nucleus
4. gFanconi_DNA_st1*@Nucleus → gFanconi_DNA_st2*@Nucleus
5. gFanconi_DNA_st2*@Nucleus → gFanconi_DNA_st3*@Nucleus
6. FANCD2|​pho@Nucleus → FANCD2|​K561_ubi|​pho@Nucleus
7. FANCI|​pho@Nucleus → FANCI|​K523_ubi|​pho@Nucleus
8. gFanconi_DNA_st4*@Nucleus → gFanconi_DNA_st5*@Nucleus
9. FANCD2@Nucleus → FANCD2|​pho@Nucleus
10. FANCD2|​K561_ubi|​pho@Nucleus + MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus + ATR|​pho|​active@Nucleus → ATR|​pho:​FANCD2|​K561_ubi|​pho:​MRE11*:​NBS1*|​S343_pho:​RAD50@Nucleus
11. gGG-NER_DNA_st1*@Nucleus → gGG-NER_DNA_st2*@Nucleus
12. gTLS_DNA_st1*@Nucleus → gTLS_DNA_st2*@Nucleus