Protein CyclinE*
Identifiers
cyclin E1
HUGO:CCNE1, HGNC:1589, ENTREZ:898, UNIPROT:P24864
cyclin E2
HUGO:CCNE2, HGNC:1590, ENTREZ:9134, UNIPROT:O96020
HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1
HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair
/ G1_CC_PHASE
HMC:EVADING_GROWTH_SUPPRESSORS
Survival
/ PI3K_AKT_MTOR
References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
PMID:18636226
PMID:15147722
PMID:14536078
CyclinE*|T380_pho@Nucleus
References
s_akt2_re53:( Survival
) PMID:14536078
CyclinE*|T380_pho|S384_pho@Nucleus
References
s_akt2_re54:( Survival
) PMID:14536078
Modifications:
In compartment: Nucleus
- CyclinE*@Nucleus
- CyclinE*|T380_pho@Nucleus
- CyclinE*|T380_pho|S384_pho@Nucleus
- CyclinE*|T380_pho|S384_pho|ubi@Nucleus
Participates in complexes:
In compartment: Nucleus
- CyclinE*:p107*@Nucleus
- CIP1_KIP1*:CyclinE*@Nucleus
- CDK2|Y14/15_pho:CyclinE*@Nucleus
- (CDK2|T160_pho:CyclinE*)|active@Nucleus
- CDK2|T160_pho|Y14/15_pho:CyclinE*@Nucleus
Participates in reactions:
As Reactant or Product:- CIP1_KIP1*@Nucleus
+ ce_s3119 →
CIP1_KIP1*:CyclinE*@Nucleus
- CIP1_KIP1*:CyclinE*@Nucleus
→
ce_s3119 + CIP1_KIP1*@Nucleus
- p107*@Nucleus
+ ce_s3119 →
CyclinE*:p107*@Nucleus
- ce_s3119 →
CDK2|Y14/15_pho:CyclinE*@Nucleus
- CDK2|Y14/15_pho:CyclinE*@Nucleus
→
CDK2|T160_pho|Y14/15_pho:CyclinE*@Nucleus
- CyclinE*@Nucleus
+ CDK2@Nucleus
→
ce_s3119
- rCyclinE*@Nucleus
→
CyclinE*@Nucleus
- CDK2|T160_pho|Y14/15_pho:CyclinE*@Nucleus
→
(CDK2|T160_pho:CyclinE*)|active@Nucleus
- ce_s3119 →
CyclinE*@Nucleus
+ CDK2@Nucleus
- CyclinE*@Nucleus
→
degraded
- ce_s3119 →
CyclinE*|T380_pho@Nucleus
- CyclinE*|T380_pho@Nucleus
→
CyclinE*|T380_pho|S384_pho@Nucleus
- CyclinE*|T380_pho|S384_pho@Nucleus
→
CyclinE*|T380_pho|S384_pho|ubi@Nucleus
As Catalyser:- G1 phase@Nucleus
→
S phase@Nucleus
- E2F1:RB1@Nucleus
→
E2F1:RB1|pho@Nucleus
- E2F4_5*:p107*@Nucleus
→
E2F4_5*:p107*|pho@Nucleus
- CIP1_KIP1*@Nucleus
→
degraded
- ORC4*@Nucleus
+ ORC5*@Nucleus
+ ORC6*@Nucleus
+ ORC3*@Nucleus
+ ORC2*@Nucleus
+ ORC1*@Nucleus
→
ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@Nucleus
- MCM5@Nucleus
+ MCM6@Nucleus
+ MCM7@Nucleus
+ MCM2@Nucleus
+ MCM3@Nucleus
+ MCM4@Nucleus
→
MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@Nucleus
- ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*@Nucleus
+ MCM2:MCM3:MCM4:MCM5:MCM6:MCM7@Nucleus
+ CDT1@Nucleus
+ CDC6@Nucleus
+ CDC45@Nucleus
+ POLA*@Nucleus
+ PRIM*@Nucleus
+ RPA1@Nucleus
+ RPA2@Nucleus
+ RPA3@Nucleus
→
CDC45:CDC6:CDT1:MCM2:MCM3:MCM4:MCM5:MCM6:MCM7:ORC1*:ORC2*:ORC3*:ORC4*:ORC5*:ORC6*:POLA*:PRIM*@Nucleus
- FOXO*@Nucleus
→
FOXO*|unk@Nucleus