Complex CUL3:Caspase8,10*:DR4/5*:RBX1 map
Complex composition:

  1. RBX1 map
  2. CUL3 map
  3. DR4/5* map
  4. Caspase8,10* map

CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol

Identifiers
NAME:CUL3:Caspase8,10*:DR4/5*:RBX1

References
Caspase8,10*:FADD:TRAIL*:DR4/5*:RBX1:CUL3
PMID:20531300
caspase-8 is polyubiquitylated at the DISC in response to Apo2L/TRAIL
PMID:19090789
PMID:23845861
rc_re1645( Regulated Cell Death  map ):
PMID:19427028
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
rc_re1646:( Regulated Cell Death  map ) PMID:20599425
rc_re1648( Regulated Cell Death  map ):
PMID:18545270
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
PMID:14744430
The ubiquitin-binding protein p62/sequestosome-1 promoted aggregation of CUL3-modified caspase-8 within p62-dependent foci, leading to full activation and processing of the enzyme and driving commitment to cell death
rc_re1649( Regulated Cell Death  map ):
PMID:15760909
endogenous c-FLIP(L) functions primarily as an inhibitor of death receptor-mediated apoptosis

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. CUL3:​RBX1@Cytosol map + Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map → map CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map
  2. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map → map Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  3. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map → map rc_s6308
  4. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map + CFLAR@Cytosol map + RIPK1@Cytosol map + RIPK3@Cytosol map + MLKL@Cytosol map → map CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map + CUL3:​RBX1@Cytosol map
As Catalyser: