Catalysis

1. 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol

Inhibition

1. STAT3|​S727_pho@Cytosol
2. HSP90*@Cytosol

References
PMID:10973499
in vitro reconstitution of the E3-ligase activity, with VHL, elonginB/C, RBX1,CUL2
PMID:18985005
in COS monkey kidney cells and Caki-I human renal carcinoma cells, inhibition of VHL-mediated HIF1A ubiquitinylation and degradation by ectopically expressed constitutively active STAT3