Protein _beta_TRCP* map

Identifiers
beta-transducin repeat containing
HUGO:BTRC, HGNC:1144, ENTREZ:8945, UNIPROT:Q9Y297
beta-transducin repeat containing E3 ubiquitin protein ligase
F-box and WD repeat domain containing 11
HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1
Beta-transducin repeat domain
HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC
BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696
HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G1_S_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / S_PHASE_CHECKPOINT  map
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_CANONICAL  map

References
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint.
Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
For checkpoint
PMID:15459660
synonym:beta-TrCP1
synonym:beta-TrCP2
PMID:15340381
PMID:15071497
E3 Ligase subunit

_beta_TRCP*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map

References
rc_re519:( Regulated Cell Death  map ) PMID:17053147

Modifications:
In compartment: Cytosol
  1. _beta_TRCP*@Cytosol map
In compartment: Nucleus
  1. _beta_TRCP*@Nucleus map
Participates in complexes:
In compartment: Cytoplasm
  1. CUL1:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm map
  2. CUL1:​RBX1:​SKP1:​_beta_TRCP*@Cytoplasm map
  3. CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm map
  4. CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​NEDD8:​PKD*:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_TRCP*@Cytoplasm map
  5. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm map
In compartment: Cytosol
  1. CUL1:​RBX1:​SKP1:​_beta_TRCP*@Cytosol map
  2. CUL4A:​DDB1:​RBX1:​_beta_TRCP*@Cytosol map
In compartment: Nucleus
  1. CUL1:​RBX1:​SKP1:​SKP2:​_beta_TRCP*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. _beta_TRCP*@Nucleus map + SKP1@Nucleus map + CUL1@Nucleus map + RBX1@Nucleus map + SKP2@Nucleus map → map CUL1:​RBX1:​SKP1:​SKP2:​_beta_TRCP*@Nucleus map
  2. E1*@Cytoplasm map + RAD6*@Cytoplasm map + NEDD8@Cytoplasm map + CUL1:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm map + FAF*@Cytoplasm map → map CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm map
  3. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm map + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm map → map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm map
  4. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm map → map CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​NEDD8:​PKD*:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_TRCP*@Cytoplasm map + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm map + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm map
As Catalyser:
  1. FANCM|​pho@Nucleus map → map degraded
  2. CyclinD*@Nucleus map → map degraded
  3. CyclinE*@Nucleus map → map degraded
  4. CDC25A@Nucleus map → map degraded
  5. CDC25B@Nucleus map → map degraded
  6. WEE1|​pho@Nucleus map → map degraded
  7. EMI1*|​pho@Nucleus map → map degraded
  8. DDIT4|​pho@Cytosol map → map DDIT4|​pho|​ubi@Cytosol map
  9. NFKBIA|​pho@Cytosol map → map NFKBIA|​pho|​ubi@Cytosol map
  10. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytosol map → map degraded
  11. PDCD4|​pho@Cytosol map → map PDCD4|​pho|​ubi@Cytosol map
  12. PHLPP*|​S869_pho|​S847_pho@Cytoplasm map → map PHLPP*|​S869_pho|​S847_pho|​ubi|​ubi@Cytoplasm map
  13. PDCD4|​S67_pho@Cytoplasm map → map PDCD4|​S67_pho|​ubi@Cytoplasm map
  14. GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho:​SUFU:​ULK3@Cytosol map → map GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho|​ubi|​ubi|​ubi|​ubi:​SUFU:​ULK3@Cytosol map
  15. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho:​SUFU:​ULK3@Cytosol map → map GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi:​SUFU:​ULK3@Cytosol map
  16. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map → map GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol map
  17. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm map + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm map → map AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm map