Catalysis

1. SQSTM1@Cytosol

References
PMID:18545270
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
PMID:14744430
caspase-8 is polyubiquitylated at the DISC in response to Apo2L/TRAIL
PMID:20531300
PMID:19427028
The ubiquitin-binding protein p62/sequestosome-1 promoted aggregation of CUL3-modified caspase-8 within p62-dependent foci, leading to full activation and processing of the enzyme and driving commitment to cell death