Complex 2-oxoglutarate:CUL2:O_sub_2_endsub_:RACK1*:RBX1:TCEB1:TCEB2:VHL map
Complex composition:

  1. VHL map
  2. RBX1 map
  3. TCEB2 map
  4. TCEB1 map
  5. RACK1* map
  6. CUL2 map
  7. O_sub_2_endsub_ map
  8. 2-oxoglutarate map

2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol

Identifiers
NAME:2-oxoglutarate:CUL2:O_sub_2_endsub_:RACK1*:RBX1:TCEB1:TCEB2:VHL

References
rc_re386( Regulated Cell Death  map ):
PMID:10973499
in vitro reconstitution of the E3-ligase activity, with VHL, elonginB/C, RBX1,CUL2
PMID:18985005
in COS monkey kidney cells and Caki-I human renal carcinoma cells, inhibition of VHL-mediated HIF1A ubiquitinylation and degradation by ectopically expressed constitutively active STAT3
rc_re387( Regulated Cell Death  map ):
PMID:12351678
identification of PHD2 as a HIF1A prolyl hydroxylase
PMID:15652751
inhibition of HIF1A prolyl hydroxylation by succinate and fumarate
PMID:15721254
in 293 cells, OS9 interacts with HIF1 and PHD and promotes HIF1A prolylhydroxylation and degradation

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. HIF1A@Cytosol map + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map + 2-oxoglutarate:​CUL2:​O_sub_2_endsub_:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytosol map → map HIF1A|​P564_hyd@Cytosol map + succinate@Cytosol map + CO_sub_2_endsub_@Cytosol map
As Catalyser:
  1. HIF1A|​P564_hyd@Cytosol map → map HIF1A|​ubi|​P564_hyd@Cytosol map