Complex Caspase8,10*:DR4/5* map
Complex composition:

  1. DR4/5* map
  2. Caspase8,10* map

Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol

Identifiers
NAME:Caspase8,10*:DR4/5*

References
TRAIL*:FADD:DR4/5*:Caspase8,10*
PMID:20531300
PMID:19090789
rc_re1643( Regulated Cell Death  map ):
PMID:10894161
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
PMID:12198154
Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8
rc_re1646:( Regulated Cell Death  map ) PMID:20599425
rc_re1645( Regulated Cell Death  map ):
PMID:19427028
Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
rc_re1654( Regulated Cell Death  map ):
PMID:9430228
TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.
PMID:16166346
TRAIL promotes cell migration and invasion via a NF-kappaB-dependent pathway in human cholangiocarcinoma cell lines

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. rc_s5142 + Caspase8,10*@Cytosol map → map Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  2. CUL3:​RBX1@Cytosol map + Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map → map CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map
  3. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map → map Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map
  4. Caspase8,10*:​DR4/5*|​gly|​pal@Cytosol map + TRAF2@Cytosol map + IKBKG@Cytosol map + TRADD@Cytosol map + RIPK1@Cytosol map → map Caspase10*:​Caspase8*@Cytosol map
As Catalyser: