Identifiers
ubiquitin-like modifier activating enzyme 1
HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1
ubiquitin-like modifier activating enzyme 2
HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2
ubiquitin-like modifier activating enzyme 5
HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5
ubiquitin-like modifier activating enzyme 6
HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6
ubiquitin-like modifier activating enzyme 7
HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7
ubiquitin-like modifier activating enzyme 3
HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3
ENREZ:79876
POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / HEDGEHOG 
 Survival   / PI3K_AKT_MTOR 
 Survival   / WNT_CANONICAL 
 Survival   / WNT_NON_CANONICAL 

References
PMID:15340381
PMID:12820959
PMID:19352404
SAE1/SAE2

References
su_akt1_s_akt1_re75:( Survival  ) PMID:17053147
su_akt1_s_akt1_re136( Survival  ):
PMID:10514377
PMID:17635922
su_akt1_s_akt1_re158:( Survival  ) PMID:19797085
su_akt1_s_akt1_re180:( Survival  ) PMID:18308511
su_akt1_s_akt1_re181:( Survival  ) PMID:18298802
su_akt1_s_akt1_re182:( Survival  ) PMID:18381890
su_akt1_s_akt1_re184:( Survival  ) PMID:18787170
su_akt1_s_akt2_re75:( Survival  ) PMID:19321440
su_akt1_s_akt2_re127:( Survival  ) PMID:15084260
su_wnc1_s_wnc2_re68:( Survival  ) PMID:15489953
su_wnc1_s_wnc2_re72( Survival  ):
Where exactly MDM2 ubiquitinates NFAT is not known and also not known if it is in the cytosol or nucleus.
PMID:16307918
su_wca1_s_wca1_re46( Survival  ):
PMID:15688063 PMID:22730322
FAF1 acts as scaffold protein

References
s_akt2_re39:( Survival  ) PMID:15147722 PMID:18006823
s_akt2_re46:( Survival  ) PMID:15531880
s_akt2_re68:( Survival  ) PMID:15169778 PMID:10722742
s_akt2_re70( Survival  ):
PMID:10721693
PMID:19459846
s_akt2_re149:( Survival  ) PMID:19440234
s_wca3_re32:( Survival  ) PMID:16714285
s_wnc3_re16( Survival  ):
Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897.
PMID:15117942
s_wnc3_re18( Survival  ):
Order of sumoylation is not important.
PMID:19218564
su_shh1_s_shh2_re1:( Survival  ) PMID:20360384 PMID:16740475
su_shh1_s_shh2_re115:( Survival  ) PMID:20463034

References
su_akt1_s_akt2_re91:( Survival  ) PMID:15668399

References
s_wca3_re151:( Survival  ) PMID:22322943

References
s_shh1_re92:( Survival  ) PMID:18997815

1. E1*@Cytoplasm
2. E1*@Cytoplasm
3. E1*@Cytoplasm
4. E1*@Cytoplasm

1. E1*@Cytosol

1. E1*@Nucleus
2. E1*@Nucleus
3. E1*@Nucleus
4. E1*@Nucleus

1. CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm
2. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm

1. E1*@Cytoplasm + RAD6*@Cytoplasm + NEDD8@Cytoplasm + CUL1:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm + FAF*@Cytoplasm → CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm
2. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm
3. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm → CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​NEDD8:​PKD*:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_TRCP*@Cytoplasm + APC|​S1505_pho|​S1501_ubi|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_ubi:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho@Cytoplasm + _beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi@Cytoplasm

1. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome → Ubiquitination@Cytoplasm
2. GF:​RTK*|​pho|​pho|​hm2@Endosome → Ubiquitination@Cytoplasm
3. PHLPP*|​S869_pho|​S847_pho@Cytoplasm → PHLPP*|​S869_pho|​S847_pho|​ubi|​ubi@Cytoplasm
4. HERC1:​TSC2@Cytoplasm → Ubiquitination@Cytoplasm
5. PAM*:​TSC2@Cytoplasm → Ubiquitination@Cytoplasm
6. E3*:​TSC2@Cytoplasm → Ubiquitination@Cytoplasm
7. CUL4*:​DCAF*:​FBW5*:​RBX1:​TSC2@Cytoplasm → Ubiquitination@Cytoplasm
8. MTOR@Cytoplasm → MTOR|​Y631_ubi@Cytoplasm
9. PDCD4|​S67_pho@Cytoplasm → PDCD4|​S67_pho|​ubi@Cytoplasm
10. FOXO3|​S644_pho@Cytoplasm → FOXO3|​S644_pho|​ubi@Cytoplasm
11. su_akt1_s_akt2_s384 → su_akt1_s_akt2_s399
12. p27KIP1*|​pho@Nucleus → p27KIP1*|​pho|​pho@Nucleus
13. p27KIP1*|​pho@Cytoplasm → p27KIP1*|​pho|​ubi|​ubi|​ubi@Cytoplasm
14. MDM2|​pho|​pho@Nucleus → MDM2|​pho|​pho|​ubi@Nucleus
15. p53*@Nucleus → p53*|​ubi@Nucleus
16. FOXO3|​pho|​pho|​pho@Cytoplasm → FOXO3|​pho|​pho|​pho|​ubi@Cytoplasm
17. p53*@Nucleus → p53*|​ubi|​ubi@Nucleus
18. FOXO1|​T24_pho|​S256_pho|​S319_pho@Cytoplasm → FOXO1|​T24_pho|​S322_ubi|​S256_pho|​S319_pho@Cytoplasm
19. GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho:​SUFU:​ULK3@Cytosol → GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho|​ubi|​ubi|​ubi|​ubi:​SUFU:​ULK3@Cytosol
20. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho:​SUFU:​ULK3@Cytosol → GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi:​SUFU:​ULK3@Cytosol
21. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol → GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytosol
22. GLI1@Cytosol → GLI1|​ubi|​ubi@Cytosol
23. SUFU@Cytosol → SUFU|​K257_ubi@Cytosol
24. GLI3-190*|​unk|​active@Nucleus → GLI3-190*|​ubi|​ubi|​ubi|​ubi@Nucleus
25. GLI2-185*|​pho|​unk|​S956_emp|​active@Nucleus → GLI2-185*|​ubi|​ubi|​pho|​unk|​S956_emp|​active@Nucleus
26. HDAC1@Nucleus → HDAC1|​ubi|​ubi@Nucleus
27. AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm + CUL1:​E1*:​FAF*:​NEDD8:​RAD6*:​RBX1:​SKP*:​_beta_TRCP*@Cytoplasm + CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​PKD*:​USP15@Cytoplasm → AMER1*:​APC|​S1505_pho|​S1501_pho|​S1504_pho|​S1507_pho|​S1503_pho|​S1510_pho:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​CK2_alpha_'*:​CK2_alpha_*:​CK2_beta_*:​CSN1*:​CSN2*:​CSN3*:​CSN4*:​CSN5*:​CSN6*:​CSN7*:​CSN8*:​CUL1:​E1*:​FAF*:​GSK3*:​NEDD8:​PKD*:​PtdIns(4,5)-P2:​RAD6*:​RBX1:​SKP*:​USP15:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho|​K19_ubi|​K49_ubi:​_beta_TRCP*@Cytoplasm
28. AXIN2@Nucleus → AXIN2|​ubi@Nucleus
29. LEF_TCF*|​S166_pho|​T155_pho@Nucleus → LEF_TCF*|​S166_pho|​T155_pho|​ubi@Nucleus
30. PPP3CB:​PPP3R*@Cytoplasm → PPP3CB|​ubi|​ubi|​ubi:​PPP3R*@Cytoplasm
31. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm → NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​ubi|​ubi@Cytoplasm
32. NFAT1*@Nucleus → NFAT1*|​unk@Nucleus
33. NFAT1*|​unk@Nucleus → NFAT1*|​unk|​unk@Nucleus
34. NFAT2*@Nucleus → NFAT2*|​K702_unk|​K914_unk@Nucleus