Protein BimEL* map

Identifiers
BCL2-like 11 (apoptosis facilitator)
HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521
BCL2-like 12 (proline rich)
HUGO:BCL2L12 HGNC:13787 ENTREZ:83596 UNIPROT:Q9HB09

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
BCL2L11 splice variant

BimEL*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re436( Regulated Cell Death  map ):
PMID:12646560
in CCL39 chinese hamster lung fibroblast cell line
PMID:15486085
in IL-3 dependent mouse pro-B cell line FL5.12, upon IL-3, ERK dependent phosphorylation of BimEL on S55, S65, S100 (mouse Bim)
in vitro, ERK2 phosphorylates mouse BimEL
in mouse BAF3 cells, in TF-1 human granulocyte macrophage- colony stimulating factor-dependent er ythroleukemia cell line, and in mouse embr yonic fibroblasts when IGF-1 was used as a survival factor, an upshift in BimEL (not BimL) electrophoretic mobility upon IL3. This upshift is lost in FL5.12 if phosphosites are mutated.
PMID:19150432
rc_re440:( Regulated Cell Death  map ) reactionType:is.a
rc_re442( Regulated Cell Death  map ):
PMID:16282323
in murine BA/F3 IL3-dependent cells, multisite phosphorylation of BimEL upon IL3. Attenuated by ERK and PI3K inhibitors.
in vitro, active mouse Akt purified from IL3 treated BAF3 cells phosphorylates recombinant human BimEL. Blocked by mutation of S87
rc_re445:( Regulated Cell Death  map ) PMID:18420585

BimEL*|​S69_pho@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re436( Regulated Cell Death  map ):
PMID:12646560
in CCL39 chinese hamster lung fibroblast cell line
PMID:15486085
in IL-3 dependent mouse pro-B cell line FL5.12, upon IL-3, ERK dependent phosphorylation of BimEL on S55, S65, S100 (mouse Bim)
in vitro, ERK2 phosphorylates mouse BimEL
in mouse BAF3 cells, in TF-1 human granulocyte macrophage- colony stimulating factor-dependent er ythroleukemia cell line, and in mouse embr yonic fibroblasts when IGF-1 was used as a survival factor, an upshift in BimEL (not BimL) electrophoretic mobility upon IL3. This upshift is lost in FL5.12 if phosphosites are mutated.
PMID:19150432

BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re439:( Regulated Cell Death  map ) PMID:19150432

BimEL*|​S87_pho@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re442( Regulated Cell Death  map ):
PMID:16282323
in murine BA/F3 IL3-dependent cells, multisite phosphorylation of BimEL upon IL3. Attenuated by ERK and PI3K inhibitors.
in vitro, active mouse Akt purified from IL3 treated BAF3 cells phosphorylates recombinant human BimEL. Blocked by mutation of S87
rc_re443( Regulated Cell Death  map ):
in HepG3 cells, insulin activates Akt but not ERK, and induces interaction between 14-3-3 and Bim (IP). In the same cell line, BimEL S87 phosphorylation was not assessed. The authors propose that the 14-3-3 bind to Akt-phosphorylated BimEL

BimEL*|​ubi@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / MOMP_REGULATION  map

References
rc_re448( Regulated Cell Death  map ):
PMID:19622774
BIM interacts with NDRG1 and with CISH and CUL2 in a NDRG1 dependent manner
NDRG1 expression destabilizes BIM
rc_re446:( Regulated Cell Death  map ) PMID:18420585

Modifications:
In compartment: Cytosol
  1. BimEL*@Cytosol map
  2. BimEL*|​ubi@Cytosol map
  3. BimEL*|​S69_pho@Cytosol map
  4. BimEL*|​S87_pho@Cytosol map
  5. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. BimEL*:​DYNLL1@Cytosol map
  2. 14-3-3*|​unk:​BimEL*|​S87_pho@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytosol map → map BimEL*|​S69_pho@Cytosol map
  2. BimEL*|​S87_pho@Cytosol map → map BimEL*@Cytosol map
  3. BCL2L12@Cytosol map → map BimEL*|​ubi@Cytosol map
  4. BimEL*@Cytosol map → map BimEL*|​S69_pho@Cytosol map
  5. BimEL*|​S69_pho@Cytosol map → map BimEL*@Cytosol map
  6. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytosol map → map degraded
  7. BimEL*|​S69_pho@Cytosol map → map BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytosol map
  8. BimEL*@Cytosol map → map BCL2L11|​ubi@Cytosol map
  9. BimEL*@Cytosol map → map BimEL*|​S87_pho@Cytosol map
  10. 14-3-3*|​unk@Cytosol map + BimEL*|​S87_pho@Cytosol map → map 14-3-3*|​unk:​BimEL*|​S87_pho@Cytosol map
  11. BimEL*@Cytosol map + DYNLL1@Cytosol map → map BimEL*:​DYNLL1@Cytosol map
  12. BimEL*@Cytosol map → map BimEL*|​ubi@Cytosol map
  13. BimEL*|​ubi@Cytosol map → map BCL2L11|​ubi@Cytosol map
  14. BCL2L11|​ubi@Cytosol map → map BimEL*|​ubi@Cytosol map
As Catalyser: