Identifiers
NAME:CUL1:RBX1:SKP1:SKP2:_beta_TRCP*
Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G1_S_CHECKPOINT
Cell Cycle DNA Repair / S_PHASE_CHECKPOINT
Cell Cycle DNA Repair / G2_M_CHECKPOINT
References
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080, PMID:15459660
ce_re195( Cell Cycle DNA Repair ):
FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156