Protein MLKL map

Identifiers
mixed lineage kinase domain-like
HUGO:MLKL HGNC:26617 ENTREZ:197259 UNIPROT:Q8NB16

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
PMID:22421439
PMID:28645028
PMID:24366341
PMID:26024392
PMID:26853145
Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.
PMID:28498367

MLKL@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / GLUTAMINE_METABOLISM  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TRAIL_RESPONSE  map

References
PMID:28645028
PMID:24366341
rc_re1649( Regulated Cell Death  map ):
PMID:15760909
endogenous c-FLIP(L) functions primarily as an inhibitor of death receptor-mediated apoptosis

Modifications:
In compartment: Cytosol
  1. MLKL@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map
  2. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map
In compartment: Endosome
  1. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
Participates in reactions:
As Reactant or Product:
  1. RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map + MLKL@Cytosol map + GLUL@Cytosol map + GLUD1@Cytosol map + PYGL@Cytosol map + PGAM5@Cytosol map → map GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map
  2. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map Glycogen breakdown@Cytosol map
  3. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map Glutaminolysis@Cytosol map
  4. GLUD1:​GLUL:​MLKL|​S358_pho|​T357_pho:​PGAM5|​pho:​PYGL:​RIPK1|​S161_pho:​RIPK3|​S199_pho|​S227_pho@Cytosol map → map PARP activation@Cytosol map
  5. CUL3:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​RBX1@Cytosol map + CFLAR@Cytosol map + RIPK1@Cytosol map + RIPK3@Cytosol map + MLKL@Cytosol map → map CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map + CUL3:​RBX1@Cytosol map
  6. CFLAR:​Caspase8,10*|​ubi:​DR4/5*|​gly|​pal:​MLKL:​RIPK3@Cytosol map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
  7. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  8. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
  9. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
  10. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  11. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
As Catalyser:
  1. ATP@Mitochondrial Matrix map + ADP@Mitochondrial intermembrane space map → map ATP@Mitochondrial intermembrane space map + ADP@Mitochondrial Matrix map
  2. GLUL|​unk@Cytosol map → map GLUL|​unk|​hm8@Cytosol map
  3. Drp1*|​pho@Cytosol map → map Drp1*@Cytosol map
  4. JNK1*@Cytosol map → map JNK1*|​pho|​active@Cytosol map