Identifiers
HUGO:IKBKB
inhibitor of nuclear factor kappa B kinase subunit beta
HUGO:IKBKB hgnc_id:HGNC:5960 HGNC:5960 ENTREZ:3551 UNIPROT:O14920
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920
HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 GENECARDS:IKBKB REACTOME:57216 KEGG:3551 ATLASONC:GC_IKBKB WIKI:IKBKB

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 

References
PMID:12133805
PMID:16818229
IKK2 (IKBKB) phoshorylates BCL10 downstream of TCR.
Mutation of the IKKbeta phosphorylation sites on Bcl10 enhances expression of NF-kappaB target genes IL-2 and TNFalpha after activation of primary T cells.
PMID:17363905
PKC-?? regulates TGF-?????activated kinase 1 (TAK1), a member of the MAPKK kinase family, leading to activation (phosphorylation)of IKK and NF-??B in a CARMA1-independent manner in the TCR pathway
PMID:20138012
To determine whether the tumor-promoting activity of the fibroblasts was dependent on NF-??B, we knocked down Ikk?? in CAFs using shRNA (Figure 5C). Knockdown of IKK?? did not have an effect in vitro on CAF survival (data not shown). IKK??-shRNA CAFs were then coinjected orthotopically with PDSC5 cells. Tumors coinjected with shRNA IKK?? fibroblasts grew significantly slower than did tumors coinjected with control fibroblasts
PMID:28462531
PMID:17485448
TNIP3 (ABIN3???) ???inhibits IKK complex trough direct binding to IKBKG.
It results in inhibition of??? ???FNKBIA phosphorylation and
proteasomal degradation and prevents activation
of downstream??? ???NFkB??? ???signaling??? ???downstream of IL10.
PMID:22435554, PMID:15485931, PMID:21217011, PMID:15199157
Agonist stimulation induces IKK2, a catalytic subunit of the IKK complex, to phosphorylate p105. These phosphorylations
create a binding site for the ubiquitin E3 ligase complex SCF-bTrCP which catalyzes K48-linked polyubiquitination of p105, followed by its proteasomal
degradatio. This releases TPL-2 from p105 inhibition and allows TPL-2 to access its substrate MEK
PMID:20300203
PMID:17693255
PMID:18716620

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

References
PMID:28462531
rc_re308( Regulated Cell Death  ):
PMID:18408758
in human epithelial ovarian cancer cells
rc_re355:( Regulated Cell Death  ) PMID:17693255
rc_re411( Regulated Cell Death  ):
PMID:19818716
PMID:23030059
rc_re648( Regulated Cell Death  ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:11741536
in MCF7 upon TNF
in Hela upon TNF + CHX
rc_re1026( Regulated Cell Death  ):
PMID:15184672
in Jurkat, nitrosothiol mediated S-nitrosylation of IKKbeta Cys179 correlates with its inactivation

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

References
rc_re411( Regulated Cell Death  ):
PMID:19818716
PMID:23030059

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / TNF_RESPONSE 

References
rc_re1026( Regulated Cell Death  ):
PMID:15184672
in Jurkat, nitrosothiol mediated S-nitrosylation of IKKbeta Cys179 correlates with its inactivation

References
s_akt1_re171:( Survival  ) PMID:17693255

1. IKK_beta_*@Cytoplasm

1. IKK_beta_*@Cytosol
2. IKK_beta_*|​ubi@Cytosol
3. IKK_beta_*|​-SNO@Cytosol

1. IKK_beta_*@Nucleus

1. IKBKG:​IKK_alpha_*:​IKK_beta_*@Cytosol
2. IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@Cytosol

1. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol
2. IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol
3. IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol

1. CHUK:​IKBKG:​IKK_beta_*@TNFRSF1 Receptor Complex
2. CHUK:​IKBKG:​IKK_beta_*|​pho@TNFRSF1 Receptor Complex

1. IKBKG:​IKK_alpha_*:​IKK_beta_*@T_cell
2. IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@T_cell

1. IKBKG:​IKK_alpha_*:​IKK_beta_*@T_cell → IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@T_cell
2. IKBKG:​IKK_alpha_*:​IKK_beta_*@Cytosol → IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@Cytosol
3. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol → IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol
4. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol + TNIP3@INNATE_IMMUNE_CELL_Cytosol → IKBKG:​IKK_alpha_*:​IKK_beta_*:​TNIP3@INNATE_IMMUNE_CELL_Cytosol
5. IKK_beta_*@Cytosol + NO@Cytosol → IKK_beta_*|​-SNO@Cytosol
6. IKK_beta_*@Cytosol + CHUK@Cytosol + IKBKG@TNFRSF1 Receptor Complex → CHUK:​IKBKG:​IKK_beta_*@TNFRSF1 Receptor Complex
7. CHUK:​IKBKG:​IKK_beta_*@TNFRSF1 Receptor Complex → CHUK:​IKBKG:​IKK_beta_*|​pho@TNFRSF1 Receptor Complex
8. IKK_beta_*@Cytosol → Survival@Cytosol
9. CHUK:​IKBKG:​IKK_beta_*|​pho@TNFRSF1 Receptor Complex → Survival@Cytosol
10. rIKBKB@Nucleus → IKK_beta_*@Cytosol
11. IKK_beta_*@Cytosol → IKK_beta_*|​ubi@Cytosol
12. IKK_beta_*|​ubi@Cytosol → degraded
13. IKK_beta_*@Cytosol → cleaved~IKBKB*@Cytosol
14. IKK_beta_*@Nucleus → Chromosome integrity and DSB repair@Nucleus
15. rRAD51@Nucleus → IKK_beta_*@Nucleus

1. IkB*:​NFKB1_p50*:​RELA@T_cell → IkB*|​pho:​NFKB1_p50*:​RELA@T_cell
2. IkB*:​NFKB1_p50*:​RELB@T_cell → IkB*|​pho:​NFKB1_p50*:​RELB@T_cell
3. IkB*:​NFKB1_p50*:​cREL*@T_cell → IkB*|​pho:​NFKB1_p50*:​cREL*@T_cell
4. BCL10@T_cell → BCL10|​pho@T_cell
5. IkB*:​NFKB1_p50*:​RELA@Cytosol → IkB*|​pho:​NFKB1_p50*:​RELA@Cytosol
6. IkB*:​NFKB1_p50*:​RELB@Cytosol → IkB*|​pho:​NFKB1_p50*:​RELB@Cytosol
7. gTNF@INNATE_IMMUNE_CELL_Cytosol → rTNF@INNATE_IMMUNE_CELL_Cytosol
8. gIL12p40*@INNATE_IMMUNE_CELL_Cytosol → rIL12p40*@INNATE_IMMUNE_CELL_Cytosol
9. gIL8*@INNATE_IMMUNE_CELL_Cytosol → rIL8*@INNATE_IMMUNE_CELL_Cytosol
10. gIL6@INNATE_IMMUNE_CELL_Cytosol → rIL6@INNATE_IMMUNE_CELL_Cytosol
11. STAT1@INNATE_IMMUNE_CELL_Cytosol → STAT1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
12. IkB*:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol → IkB*|​pho:​NFKB1_p50*:​RELA@INNATE_IMMUNE_CELL_Cytosol
13. IkB*:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol → IkB*|​pho:​NFKB1_p50*:​RELB@INNATE_IMMUNE_CELL_Cytosol
14. IkB*:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol → IkB*|​pho:​NFKB1_p50*:​cREL*@INNATE_IMMUNE_CELL_Cytosol
15. MAP3K8:​NFKB1_p105*:​TNIP2@INNATE_IMMUNE_CELL_Cytosol → NFKB1_p105*|​pho@INNATE_IMMUNE_CELL_Cytosol + MAP3K8@INNATE_IMMUNE_CELL_Cytosol + TNIP2@INNATE_IMMUNE_CELL_Cytosol
16. NFKBIA@Cytosol → NFKBIA|​pho@Cytosol
17. TSC1:​TSC2|​M1_unk@Cytosol → TSC1|​S487_pho|​S511_pho:​TSC2|​M1_unk@Cytosol
18. TSC1@Endosome Membrane → TSC1|​pho|​pho@Endosome Membrane