Protein NFE2L2 map

Identifiers
nuclear factor (erythroid-derived 2)-like 2
HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / ER_STRESS  map
 Regulated Cell Death  map  / FERROPTOSIS  map

References
PMID:23850759
NOTE: * means activated form

NFE2L2|​ubi@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re416( Regulated Cell Death  map ):
PMID:19560419
CDKN1A interacts directly with NFE2L2, thus competing with KEAP1 binding

NFE2L2@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re418:( Regulated Cell Death  map ) reactionType:is.a
rc_re311( Regulated Cell Death  map ):
PMID:19747488
in HepG2, by NFkB, upon copper exposure
PMID:18761713
in rat cortical neurons, by NFE2L2
PMID:19027064
in mouse lung, by NFE2L2
proposed also in human, and deregulation in patients with chronic obstructive pulmonary disorder
rc_re869( Regulated Cell Death  map ):
PMID:10874044
in MCF7 by NFE2L2, upon cadmium exposure
PMID:10821856
in mouse primary peritoneal macrophages, by NFE2L2
PMID:12356737
by BACH1
PMID:12511571
in A549 by BACH1 upon hypoxia
rc_re1006( Regulated Cell Death  map ):
PMID:16219762
in PC12 by NFE2L2 upon 4-HNE
PMID:15521073
in bovine arterial endothelial cells, by NFE2L2, upon cadmium
PMID:17512463
in mouse photoreceptor-derived 661W cells, by NFE2L2, upon 4-HNE
rc_re1009( Regulated Cell Death  map ):
PMID:11279008
in K562 human myelogenous leukaemia line, by NFE2L2, upon hemin
rc_re1014( Regulated Cell Death  map ):
PMID:11909699
in HepG2
rc_re1017( Regulated Cell Death  map ):
PMID:10441483
in vitro with HepG2 nuclear extracts for gel (super)shift assay

Modifications:
In compartment: Cytosol
  1. NFE2L2@Cytosol map
  2. NFE2L2|​pho@Cytosol map
  3. NFE2L2|​ubi@Cytosol map
In compartment: Nucleus
  1. NFE2L2@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. KEAP1:​NFE2L2@Cytosol map
  2. KEAP1:​NFE2L2@Cytosol map
In compartment: Nucleus
  1. NFE2L2:​small~MAF*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. NFE2L2@Cytosol map → map NFE2L2|​pho@Cytosol map
  2. KEAP1@Cytosol map + NFE2L2@Cytosol map → map KEAP1:​NFE2L2@Cytosol map
  3. NFE2L2@Cytosol map + KEAP1@Cytosol map → map KEAP1:​NFE2L2@Cytosol map
  4. NFE2L2@Cytosol map → map NFE2L2@Nucleus map
  5. NFE2L2@Nucleus map + small~MAF*@Nucleus map → map NFE2L2:​small~MAF*@Nucleus map
  6. NFE2L2@Cytosol map → map NFE2L2|​ubi@Cytosol map
  7. NFE2L2|​ubi@Cytosol map → map degraded
  8. NFE2L2:​small~MAF*@Nucleus map → map NFE2L2@Nucleus map
  9. NFE2L2@Cytosol map → map NFE2L2@Nucleus map
As Catalyser:
  1. gTXNRD1@Nucleus map → map rTXNRD1@Nucleus map
  2. gTXN@Nucleus map → map rTXN@Nucleus map
  3. gGCLC@Nucleus map → map rGCLC@Nucleus map
  4. gGCLM@Nucleus map → map rGCLM@Nucleus map
  5. gNQO1@Nucleus map → map rNQO1@Nucleus map
  6. gSRXN1@Nucleus map → map rSRXN1@Nucleus map
  7. NFE2L2@Cytosol map → map NFE2L2|​ubi@Cytosol map
  8. gHMOX1@Nucleus map → map rHMOX1@Nucleus map
  9. gPRDX1@Nucleus map → map rPRDX1@Nucleus map