Identifiers
Cyclin D1
HUGO:CCND1, HGNC:1582, ENTREZ:595, UNIPROT:P24385
Cyclin D2
HUGO:CCND2, HGNC:1583, ENTREZ:894, UNIPROT:P30279
Cyclin D3
HUGO:CCND3, HGNC:1585, ENTREZ:896, UNIPROT:P30281
HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1
HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2
HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair   / G1_CC_PHASE 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 

References
PMID:20068082, PMID:16236519, PMID:18590585, PMID:19075565, PMID:18786381, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786
PMID:18414028
PMID:19887899

References
s_akt1_re98:( Survival  ) PMID:19887899

References
s_akt2_re137:( Survival  ) PMID:11124803

1. CyclinD*@Cytoplasm

1. CyclinD*@Nucleus
2. CyclinD*|​pho@Nucleus
3. CyclinD*|​T286_pho@Nucleus

1. CRM1*:​CyclinD*|​T286_pho@Cytoplasm
2. CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm
3. CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm

1. CDK4_6*:​CyclinD*@Nucleus
2. CDK4_6*:​CyclinD*|​pho@Nucleus
3. CRM1*:​CyclinD*|​T286_pho@Nucleus
4. CDK4_6*|​Y14_pho:​CyclinD*@Nucleus
5. CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@Nucleus
6. (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus
7. CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus
8. CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus
9. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus

1. CyclinD*@Nucleus + CDK4_6*@Nucleus → CDK4_6*:​CyclinD*@Nucleus
2. CyclinD*@Nucleus → degraded
3. (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus + CIP1_KIP1*@Nucleus → (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus
4. (CDK4_6*:​CIP1_KIP1*:​CyclinD*)|​active@Nucleus → CIP1_KIP1*@Nucleus + (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus
5. CDK4_6*:​CyclinD*@Nucleus → CDK4_6*|​Y14_pho:​CyclinD*@Nucleus
6. CDK4_6*|​Y14_pho:​CyclinD*@Nucleus → CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@Nucleus
7. CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@Nucleus → (CDK4_6*|​T172_pho:​CyclinD*)|​active@Nucleus
8. CDK4_6*:​CyclinD*@Nucleus → CDK4_6*:​CyclinD*|​pho@Nucleus
9. CDK4_6*:​CyclinD*|​pho@Nucleus → CyclinD*|​pho@Nucleus + CDK4_6*@Nucleus
10. CyclinD*|​pho@Nucleus → CyclinD*@Nucleus
11. rCyclinD*@Nucleus → CyclinD*@Nucleus
12. CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm → su_akt1_s_akt1_s736
13. CDK4_6*@Cytoplasm + p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm + CyclinD*@Cytoplasm → CDK4_6*:​CyclinD*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Cytoplasm
14. su_akt1_s_akt2_s120 → CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus
15. CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus → CyclinD*|​T286_pho@Nucleus + p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus + CDK4_6*@Nucleus
16. CyclinD*|​T286_pho@Nucleus + CRM1*@Nucleus → CRM1*:​CyclinD*|​T286_pho@Nucleus
17. CRM1*:​CyclinD*|​T286_pho@Nucleus → CRM1*:​CyclinD*|​T286_pho@Cytoplasm
18. p21CIP1*|​pho|​pho@Nucleus + CyclinD*|​T286_pho@Nucleus + CDK4_6*@Nucleus → CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus
19. CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus → G1 phase@Nucleus
20. CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm → su_akt1_s_akt2_s120
21. rCyclinD*@Nucleus → CDK4_6*:​CyclinD*:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Cytoplasm

1. G1 phase@Nucleus → S phase@Nucleus
2. E2F1:​RB1@Nucleus → E2F1:​RB1|​pho@Nucleus
3. E2F4_5*:​p107*@Nucleus → E2F4_5*:​p107*|​pho@Nucleus