Protein BCL2L11 map

Identifiers
HUGO:BCL2L11
BCL2-like 11 (apoptosis facilitator)
HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map
 Regulated Cell Death  map  / ER_STRESS  map

References
PMID:23850759
PMID:23430059
synonym:BIM

BCL2L11|​S58_pho|​T56_pho|​S44_pho@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re435:( Regulated Cell Death  map ) reactionType:is.a

BCL2L11|​S58_unk|​T56_unk|​S44_unk@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re435:( Regulated Cell Death  map ) reactionType:is.a

BCL2L11@Mitochondrial inner membrane

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re14( Regulated Cell Death  map ):
PMID:15486085
in FL5.12 cells correlation of BIM-BAX interaction in mitochondrial fractions with presence of unphosphorylated S65 BimEL
non phosphorylatable BimEL: enhanced interaction with BAX and enhanced proapoptotic activity
PMID:12419244
in vitro in reconstituted vesicles, BID induces BAX and membrane permeabilization
rc_re582( Regulated Cell Death  map ):
PMID:9430630
BCL2-BimEL interaction in mitochondrial fraction independent of BIM S69 phosphorylation status
PMID:15724238
in human tonsil B cells, constitutive interaction
PMID:10198631
rc_re583( Regulated Cell Death  map ):
rc_re586( Regulated Cell Death  map ):
MCL1-BIM interaction in mitochondrial fraction independent of BIM S65 phosphorylation status

BCL2L11|​ubi@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / APOPTOSIS  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re444:( Regulated Cell Death  map ) PMID:18420585

Modifications:
In compartment: Cytosol
  1. BCL2L11@Cytosol map
  2. BCL2L11|​ubi@Cytosol map
  3. BCL2L11|​S58_pho|​active@Cytosol map
  4. BCL2L11|​S58_pho|​T56_pho|​S44_pho@Cytosol map
  5. BCL2L11|​S58_unk|​T56_unk|​S44_unk@Cytosol map
In compartment: Endopasmic Reticulum
  1. BCL2L11@Endopasmic Reticulum map
In compartment: Mitochondrial inner membrane
  1. BCL2L11@Mitochondrial inner membrane map
In compartment: T_cell
  1. BCL2L11@T_cell map
Participates in complexes:
In compartment: Cytosol
  1. BCL2L11:​DYNLL1@Cytosol map
  2. BCL2L11|​S58_pho|​T56_pho|​S44_pho:​DYNLL1@Cytosol map
In compartment: Endopasmic Reticulum
  1. BCL2L11:​IRE1-alpha*@Endopasmic Reticulum map
In compartment: Mitochondrial inner membrane
  1. BCL2:​BCL2L11@Mitochondrial inner membrane map
  2. BCL2L11:​MCL1@Mitochondrial inner membrane map
  3. BCL2A1:​BCL2L11@Mitochondrial inner membrane map
  4. BCL2L11:​BCL2L2@Mitochondrial inner membrane map
  5. BCL2-XL*:​BCL2L11@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. rBCL2L11@T_cell map → map BCL2L11@T_cell map
  2. BCL2L11@T_cell map → map Regulation_of_T-cell_apoptosis@T_cell map
  3. BCL2L11|​S58_pho|​T56_pho|​S44_pho@Cytosol map → map BCL2L11|​ubi@Cytosol map
  4. rBCL2L11@Nucleus map → map BCL2L11|​ubi@Cytosol map
  5. rBCL2L11@Nucleus map → map BCL2L11@Cytosol map
  6. BCL2L11@Cytosol map → map BCL2L11|​S58_pho|​active@Cytosol map
  7. BCL2L11|​S58_pho|​active@Cytosol map → map Apoptosis@Cytosol map
  8. IRE1-alpha*@Endopasmic Reticulum map + BCL2L11@Endopasmic Reticulum map → map BCL2L11:​IRE1-alpha*@Endopasmic Reticulum map
  9. BCL2L11|​S58_pho|​active@Cytosol map → map BCL2L11@Cytosol map
  10. BCL2L11|​ubi@Cytosol map + MIF@Cytosol map → map rc_s220
  11. BCL2L11:​DYNLL1@Cytosol map → map BCL2L11|​S58_pho|​T56_pho|​S44_pho:​DYNLL1@Cytosol map
  12. BCL2L11|​ubi@Cytosol map + DYNLL1@Cytosol map → map BCL2L11:​DYNLL1@Cytosol map
  13. BCL2L11|​S58_pho|​T56_pho|​S44_pho:​DYNLL1@Cytosol map → map DYNLL1@Cytosol map + BCL2L11|​S58_pho|​T56_pho|​S44_pho@Cytosol map
  14. BCL2L11|​S58_pho|​T56_pho|​S44_pho@Cytosol map → map BCL2L11|​S58_unk|​T56_unk|​S44_unk@Cytosol map
  15. BimEL*@Cytosol map → map BCL2L11|​ubi@Cytosol map
  16. BCL2L11|​ubi@Cytosol map → map BCL2L11|​S58_unk|​T56_unk|​S44_unk@Cytosol map
  17. BCL2L11|​ubi@Cytosol map → map degraded
  18. BimEL*|​ubi@Cytosol map → map BCL2L11|​ubi@Cytosol map
  19. BCL2L11|​ubi@Cytosol map → map BimEL*|​ubi@Cytosol map
  20. BCL2L11|​S58_unk|​T56_unk|​S44_unk@Cytosol map → map BCL2L11|​ubi@Cytosol map
  21. BCL2L11@Mitochondrial inner membrane map + BCL2|​pho@Mitochondrial inner membrane map → map BCL2:​BCL2L11@Mitochondrial inner membrane map
  22. BCL2L11@Mitochondrial inner membrane map + BCL2-XL*@Mitochondrial inner membrane map → map BCL2-XL*:​BCL2L11@Mitochondrial inner membrane map
  23. BCL2L11@Mitochondrial inner membrane map + BCL2L2@Mitochondrial inner membrane map → map BCL2L11:​BCL2L2@Mitochondrial inner membrane map
  24. BCL2L11@Mitochondrial inner membrane map + BCL2A1@Mitochondrial inner membrane map → map BCL2A1:​BCL2L11@Mitochondrial inner membrane map
  25. BCL2L11@Mitochondrial inner membrane map + MCL1|​S159_unk@Mitochondrial inner membrane map → map BCL2L11:​MCL1@Mitochondrial inner membrane map
  26. BCL2L11|​ubi@Cytosol map → map BCL2L11@Mitochondrial inner membrane map
As Catalyser:
  1. BAX|​S163_unk|​T167_unk@Mitochondrial inner membrane map → map rc_s4588
  2. ruXBP1@Nucleus map → map rsXBP1@Nucleus map