Identifiers
HUGO:SOS1
son of sevenless homolog 1 (Drosophila)
HUGO:SOS1, HGNC:11187, ENTREZ:6654, UNIPROT:Q07889 , GENECARDS:GC02M039208
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos