Identifiers
HUGO:SOS2
son of sevenless homolog 2 (Drosophila)
HUGO:SOS2, HGNC:11188, ENTREZ:6655, UNIPROT:Q07890, GENECARDS:GC14M050583
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
PMID:17673906
Upon TGFB stimulation, the activated TGFBR1 recruits and directly phosphorylates SHC1 on tyrosine and serine.
TGFB-induced SHC1 phosphorylation induces SHC1 association with Grb2 and Sos