Protein NCKAP1 map

Identifiers
NCK-associated protein 1
HUGO:NCKAP1 HGNC:7666 ENTREZ:10787 UNIPROT:Q9Y2A7

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

NCKAP1@Cytosol

References
em_emtc_emtc_re785( EMT Senescence  map ):
PMID:12181570
Rac1 binds to NCKAP1 and CYFIP2 and also promotes NCK1 binding to NCKAP1.
This binding inhibits NCKAP1 and CYFIP2 binding to WASF1 and promotes release of the complex of WASF1 and BRK1, thus activating WASF1.
Activated WASF1 then stimulates ARP2/3 that mediates actin cytoskeletal polymerizatioin
em_emtc_emtc_re802( EMT Senescence  map ):
Rac1 stimulates actin polymerization by activation of WAS protein family (WASF1 and WASF2)
PMID:16212495
PMID:9843499
PMID:16702231

Modifications:
In compartment: Cytosol
  1. NCKAP1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. GTP:​RAC1@Cytosol map → map NCKAP1@Cytosol map
    2. NCKAP1@Cytosol map → map BNIP2@Cytosol map
    3. NCK1@Cytosol map + NCKAP1@Cytosol map → map em_emtc_emtc_s2998
    As Catalyser:
    1. WASF1@Cytosol map → map WASF1@Cytosol map