Protein PAR6* map

Identifiers
par-6 partitioning defective 6 homolog alpha (C. elegans)
"par-6 (partitioning defective 6, C.elegans) homolog alpha"
HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6
par-6 partitioning defective 6 homolog beta (C. elegans)
"par-6 (partitioning defective 6, C.elegans) homolog beta"
HUGO:PARD6B HGNC:16245 ENTREZ:84612 UNIPROT:Q9BYG5
par-6 partitioning defective 6 homolog gamma (C. elegans)
"par-6 (partitioning defective 6, C.elegans) homolog gamma"
HUGO:PARD6G HGNC:16076 ENTREZ:84552 UNIPROT:Q9BYG4
HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_NON_CANONICAL  map

PAR6*@Cytosol

References
em_emtc_emtc_re771( EMT Senescence  map ):
RAC1 binds directly to PARD6 that activates PRKCZ.
This leads to establishment of the cell polarity and promotes cellular transformation.
PMID:10873802
PARD6 links Rac1 and Cdc42 to PKCzeta signaling and cell transformation.
PMID:10934475
PARD6 binds to Cdc42; Rac1; PARD3; PRKC isoforms.
In vitro, PARD3 acts as a substrate and an inhibitor of PRKC.
PARD3 and PARD6 have a scaffolding function, coordinating the activities of several signalling proteins that are implicated in mammalian cell polarity.
PMID:10954424
PARD6 is a binding partner for the Rho GTPases Cdc42 and Rac1

PAR6*@Cytoplasm

References
s_wnc1_re85( Survival  map ):
Prickle interacts physically with Vangl
PMID:22037766
PMID:12941693
Par6 is constitutively associated with Dvl
PMID:19379695

Modifications:
In compartment: Cytoplasm
  1. PAR6*@Cytoplasm map
In compartment: Cytosol
  1. PAR6*@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. PAR6*:​PRICKLE1|​pho:​RACK1*:​VANGL*@Cytoplasm map
  2. CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm map
  3. CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  4. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  5. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  6. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  7. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  8. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho|​ubi:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  9. CK1_epsilon_*:​CTHRC1:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm map
  10. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  11. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
In compartment: Endosome
  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  2. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  4. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  5. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  6. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map
  7. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
Participates in reactions:
As Reactant or Product:
  1. PAR6*@Cytosol map → map PARD6A@Cytosol map
  2. PAR6*@Cytosol map → map PARD6B@Cytosol map
  3. PAR6*@Cytosol map → map PARD6G@Cytosol map
  4. PAR6*@Cytosol map → map PAR6*@Cytosol map
  5. PAR6*@Cytosol map + em_emtc_emtc_s3011 → map em_emtc_emtc_s3035
  6. RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  7. APC2*:​GSK3*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  8. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho|​ubi:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map + RSPO3@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map + SMURF1@Cytoplasm map + PRICKLE1|​pho|​ubi@Cytoplasm map
  9. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  10. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  11. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  12. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map + WGEF*@Cytoplasm map + DAAM1@Cytoplasm map + RHOA@Cytoplasm map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  13. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map Angiogenesis@Nucleus map
  14. APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​RHOA:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DAAM1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WGEF*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map + RHOA@Cytoplasm map
  15. ROR2@Cytoplasm map + FZD*:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm map + WNT*@default map + GTP@Cytoplasm map + CK1_epsilon_*@Cytoplasm map + CTHRC1@Cytoplasm map + SYN4*@Cytoplasm map + PAR6*:​PRICKLE1|​pho:​RACK1*:​VANGL*@Cytoplasm map + PRR*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm map + GDP@Cytoplasm map
  16. CK1_epsilon_*:​CTHRC1:​FZD*:​GTP:​G_alpha_*:​G_beta_*:​G_gamma_*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm map → map GTP:​G_alpha_*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map
  17. CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*@Cytoplasm map + DVL*|​pho|​S142_emp|​S139_emp:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  18. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map WNT canonical pathway@Cytoplasm map
  19. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  20. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*|​pho|​pho|​pho|​pho:​WNT*:​_beta_-Arrestin2*@Endosome map
  21. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm map + DVL*|​pho|​S142_emp|​S139_emp|​ubi@Cytoplasm map
  22. RACK1*:​VANGL*@Cytoplasm map + PRICKLE1|​pho@Cytoplasm map + PAR6*@Cytoplasm map → map PAR6*:​PRICKLE1|​pho:​RACK1*:​VANGL*@Cytoplasm map
  23. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​RACK1*:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  24. SMURF1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
  25. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho|​ubi:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
As Catalyser:
  1. PRKCZ@Cytosol map → map PRKCZ@Cytosol map
  2. ATP6V0C_D*@Cytoplasm map → map ATP6V0C_D*@Endosome map
  3. ATP6V0C_D*@Cytoplasm map → map ATP6V0C_D*@Endosome map
  4. APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​RACK1*:​ROR2|​S864_pho|​pho|​pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map