Protein NISCH map

Identifiers
Nischarin
HUGO:NISCH HGNC:18006 ENTREZ:11188 UNIPROT:Q9Y2I1??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:11121431
PMID:15157156
PMID:15229651
Nischarin binds preferentially to the cytoplasmic tail of ITGA5 subunit ti inhibit cell migration.
Nischarin is not found in focal adhesion sites.
Once integrins enter into adhesion sites, Nischarin is released, allowing it to bind to the activated PAK1 in order to inactive PAK1..
This binding is enhaced by active Rac1.
The ability of Nischarin to inhibit PAK1 is related to its ability to inhibit cell motility.

NISCH@Nucleus

References
em_emtc_emtc_re963( EMT Senescence  map ):
PMID:11121431
PMID:15157156
PMID:15229651
Nischarin binds preferentially to the cytoplasmic tail of ITGA5 subunit ti inhibit cell migration.
Nischarin is not found in focal adhesion sites.
Once integrins enter into adhesion sites, Nischarin is released, allowing it to bind to the activated PAK1 in order to inactive PAK1..
This binding is enhaced by active Rac1.
The ability of Nischarin to inhibit PAK1 is related to its ability to inhibit cell motility.

Modifications:
In compartment: Nucleus
  1. NISCH@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. NISCH:​PAK1@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. ITGA5@Cytosol map + NISCH@Nucleus map → map em_emtc_emtc_s3457
  2. PAK1@Cytosol map + NISCH@Nucleus map → map NISCH:​PAK1@Cytosol map
  3. NISCH:​PAK1@Cytosol map → map Cell motility@Cytosol map
As Catalyser: