Complex CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* map
Complex composition:

  1. DVL* map
  2. FZD* map
  3. ROR2 map
  4. WNT* map
  5. CK1_epsilon_* map
  6. CTHRC1 map
  7. SYN4* map
  8. VANGL* map
  9. RACK1* map
  10. PAR6* map
  11. _beta_-Arrestin2* map
  12. RSPO3 map
  13. PRR* map

CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm

Identifiers
NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re111( Survival  map ):
Rspo is required for clathrin-mediated endocytosis
PMID:21397842
It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation.
PMID:16263762
s_wnc1_re112( Survival  map ):
Clathrin-mediated endocytosis
PMID:20947020
PMID:19910923
PCP MODULE splits in Rac1 branch when Dvl is not hyper-phosphorylated
PMID:18953287
s_wnc1_re114( Survival  map ):
RhoA branch of the PCP -MODULE when Dvl is hyper-phosphorylated by CK_epsilon
su_wnc1_s_wnc1_re112( Survival  map ):
su_wnc1_s_wnc1_re114( Survival  map ):

CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome

Identifiers
NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re114( Survival  map ):
Clathrin-mediated endocytosis
PMID:21397842
PMID:20947020
PMID:19910923
RhoA branch of the PCP -MODULE when Dvl is hyper-phosphorylated by CK_epsilon
PMID:18953287
s_wnc1_re109( Survival  map ):
Polymerised Dvl act as scaffold for recruiting axin.
PMID:21078818
GSK3 phosphorylates ROR2
PMID:17986005

CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome

Identifiers
NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*

References
PCP MODULE
s_wnc1_re112( Survival  map ):
Clathrin-mediated endocytosis
PMID:21397842
PMID:20947020
PMID:19910923
PCP MODULE splits in Rac1 branch when Dvl is not hyper-phosphorylated
PMID:18953287
s_wnc1_re108( Survival  map ):
Rac1 found to be associated with polymerised Dvl.
PMID:20215527
DEP domain in Dvl is enough to activate Rac
PMID:12533515
su_wnc1_s_wnc1_re108( Survival  map ):

CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome

Identifiers
NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2*

References
PCP MODULE

Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map
In compartment: Endosome
  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  2. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
Participates in reactions:
As Reactant or Product:
  1. RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  2. APC2*:​GSK3*@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map APC2*:​CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​GSK3*:​PAR6*:​PRR*:​RACK1*:​ROR2|​S864_pho:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  3. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRICKLE1|​pho|​ubi:​PRR*:​RACK1*:​ROR2:​SMURF1:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map + RSPO3@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map + SMURF1@Cytoplasm map + PRICKLE1|​pho|​ubi@Cytoplasm map
  4. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  5. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Cytoplasm map → map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_pho|​S139_pho:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  6. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map → map RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​S142_emp|​S139_emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
As Catalyser: