Protein BAIAP2 map

Identifiers
BAI1-associated protein 2
HUGO:BAIAP2 HGNC:947 ENTREZ:10458 UNIPROT:Q9UQB8

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

BAIAP2@Cytosol

References
em_emtc_emtc_re788( EMT Senescence  map ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane rufflin
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
em_emtc_emtc_re789( EMT Senescence  map ):
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling

Modifications:
In compartment: Cytosol
  1. BAIAP2@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. BAIAP2@Cytosol map → map BAIAP2@Cytosol map
    As Catalyser:
    1. WASF2@Cytosol map → map WASF2@Cytosol map