Protein ARHGEF14* map

Identifiers
MCF.2 cell line derived transforming sequence-like
HUGO:MCF2L, HGNC:14576, ENTREZ:23263, GENECARDS:GC13P113548, UNIPROT:O15068

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:7957046
OST (so-called DBS, MCF2L, ARHGEF14) encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways
PMID:14701795
Co-expression of DBS with activated Rac1 causes enhanced focus forming activity and elevated levels of GTP???RhoA in NIH3T3 cells
Interaction between activated Rac1 and DBS is specific for Rac1 and is not observed between Rac1 and several other members of the Rho-specific guanine nucleotide exchange factor family.
These results showed that activated Rac1 bt stimulation of DBS activity promotes RhoA activation.

ARHGEF14*@Cytosol

References
em_emtc_emtc_re767( EMT Senescence  map ):
PMID:14701795
Activated Rac1 activates ARHGEF14 which is a common activator for CDC2 and RHOA
Co-expression of Dbs with activated Rac1 causes enhanced focus forming activity and elevated levels of GTP-bound RhoA in NIH 3T3 cells, indicating that Dbs is activated by the interaction.

Modifications:
In compartment: Cytosol
  1. ARHGEF14*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. RhoA_GEFs*@Cytosol map → map ARHGEF14*@Cytosol map
    2. GTP:​RAC1@Cytosol map → map ARHGEF14*@Cytosol map
    As Catalyser: