Protein MAP3K7_10_11* map

Identifiers
MAP3K10_11*
mitogen-activated protein kinase kinase kinase 11
MLK3, PTK1
HUGO:MAP3K11 HGNC:6850 ENTREZ:4296 UNIPROT:Q16584
mitogen-activated protein kinase kinase kinase 10
MLK2
HUGO:MAP3K10 HGNC:6849 ENTREZ:4294 UNIPROT:Q02779
mitogen-activated protein kinase kinase kinase 7
TAK1
HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

MAP3K7_10_11*@Cytosol

References
em_emtc_emtc_re765( EMT Senescence  map ):
Rac1 activates JNK pathway vai PAK-independent mechanisms involving binding and stimulation of MAP3K (MAP3K10 and MAP3K11)
PMID:8910292
MLK3 overexpression is sufficient to activate JNK po- tently without affecting the phosphorylating activity of MAPK or p38
MLK3 binds the GTP-binding proteins Cdc42 and Rac1 in vivo and that MLK3 mediates activation of MEKK-SEK-JNK kinase cascade by Rac1 and Cdc42
PMID:9427749
MLK2 (MAP3K10) and MLK3 (MAP3K11) interact with the activated (GTP-bound) forms of Rac and Cdc42, with a slight preference for Rac.
When expressed in fibroblasts, MLK2 co-localizes with active, dually phosphorylated JNK to punctate structures along microtubules.
MLK2 and MLK3 interact with members of the KIF3 family of kinesin superfamily motor proteins and with KAP3A, the putative targeting component of KIF3 motor complex
PMID:11713255
Rac1 coordinately activates p70S6K and JNK via MLK3 activation

Modifications:
In compartment: Cytosol
  1. MAP3K7_10_11*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. MAP3K7_10_11*@Cytosol map → map MAP3K7@Cytosol map
    2. MAP3K7_10_11*@Cytosol map → map MAP3K10@Cytosol map
    3. MAP3K7_10_11*@Cytosol map → map MAP3K11@Cytosol map
    4. MAP3K7_10_11*@Cytosol map → map MAP3K7_10_11*@Cytosol map
    5. MAP3K7_10_11*@Cytosol map → map JNK pathway@Cytosol map
    As Catalyser: