Identifiers
PAK*
p21 protein (Cdc42/Rac)-activated kinase 1
"p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)", "p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)"
HUGO:PAK1 HGNC:8590 ENTREZ:5058 UNIPROT:Q13153
p21 protein (Cdc42/Rac)-activated kinase 2
"p21 (CDKN1A)-activated kinase 2"
HUGO:PAK2 HGNC:8591 ENTREZ:5062 UNIPROT:Q13177
p21 protein (Cdc42/Rac)-activated kinase 3
"mental retardation, X-linked 47", MRX30, MRX47, "p21 (CDKN1A)-activated kinase 3"
HUGO:PAK3 HGNC:8592 ENTREZ:5063 UNIPROT:O75914

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
em_emtc_emtc_re761( EMT Senescence  ):
PMID:8805275
PMID:8910277
PMID:9744077
PMID:10023776
PMID:11728826
GTP-bound Rac1 activates PAK1,2,3.
The binding of the active GTP form of Rac1 and the PBD domain of PAK1,2,3 promotes autophosphorylation of PAK1,2,3 and activation of JNK pathway.

References
em_emtc_emtc_re761( EMT Senescence  ):
PMID:8805275
PMID:8910277
PMID:9744077
PMID:10023776
PMID:11728826
GTP-bound Rac1 activates PAK1,2,3.
The binding of the active GTP form of Rac1 and the PBD domain of PAK1,2,3 promotes autophosphorylation of PAK1,2,3 and activation of JNK pathway.
em_emtc_emtc_re762( EMT Senescence  ):
The association between the active GTP-bound form of CDC42 and the PBD domain of PAK1,2,3,4 promotes PAK1,2,3,4 autophosphorylation
PMID:16204230
PMID:10461188
PMID:11950587
All 4 kinases PAK1,2,3,4 are capable of promoting JNK signaling activation that leads to cytoskeletal rearrangement and cell motility.

1. PAK*@Cytosol
2. PAK*|​pho|​active@Cytosol

1. PAK*|​pho|​active@Cytosol → PAK1@Cytosol
2. PAK*|​pho|​active@Cytosol → PAK2@Cytosol
3. PAK*|​pho|​active@Cytosol → PAK3@Cytosol
4. PAK*@Cytosol → PAK*|​pho|​active@Cytosol
5. PAK*|​pho|​active@Cytosol → JNK pathway@Cytosol
6. PAK*@Cytosol → PAK3@Cytosol
7. PAK*@Cytosol → PAK2@Cytosol
8. PAK*@Cytosol → PAK1@Cytosol