Identifiers
HUGO:AKT1S1
AKT1 substrate 1 (proline-rich)
HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36
HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MOMP_REGULATION 
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / PI3K_AKT_MTOR 

References
PMID:16469695 PMID:26159692 PMID:23087689
PMID:16469695, PMID:26159692
mTOR Complex 1 (mTORC1) is composed of mTOR itself, regulatory-associated protein of mTOR (Raptor), mammalian lethal with SEC13 protein 8 (MLST8) and the recently identified PRAS40 and DEPTOR
synonym:PRAS
 NATURAL_KILLER 
 DENDRITIC_CELL 
PMID:18372248
PMID:17604271

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / FATTY_ACID_BIOSYNTHESIS 
 Regulated Cell Death   / MOMP_REGULATION 

References
s_akt1_re113:( Survival  ) PMID:21474067

References
s_akt1_re58( Survival  ):
PMID:19446321
ANNOTATION:complex formation with DEPTOR antagonize/inhibits MTOR kinase activity
PMID:19706736
s_akt1_re61:( Survival  ) PMID:17604271

1. PRAS40*@Cytoplasm

1. PRAS40*@Cytosol

1. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome

1. 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Cytoplasm
2. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm

1. 14-3-3*|​unk:​PRAS40*|​pho@Cytosol
2. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@Cytosol
3. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@Cytosol

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@INNATE_IMMUNE_CELL_Cytosol
2. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol

1. 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome
2. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
3. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
4. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
5. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
6. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
7. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
8. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@T_cell
2. (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@T_cell

1. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@T_cell → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@T_cell
2. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@Cytosol → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@Cytosol
3. DEPTOR:​MLST8:​MTOR:​PRAS40*:​RPTOR@INNATE_IMMUNE_CELL_Cytosol → (DEPTOR:​MLST8:​MTOR|​pho:​PRAS40*:​RPTOR)|​active@INNATE_IMMUNE_CELL_Cytosol
4. rc_s5670 + PRAS40*@Cytosol → rc_s5506
5. 14-3-3*|​unk@Cytosol + rc_s5649 → rc_s5670 + 14-3-3*|​unk:​PRAS40*|​pho@Cytosol
6. PRAS40*@Cytoplasm + MLST8@Cytoplasm + RPTOR@Cytoplasm + MTOR|​pho@Cytoplasm + RAC1@Cytoplasm → MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
7. PRAS40*@Cytoplasm + MLST8@Cytoplasm + RPTOR@Cytoplasm + MTOR@Cytoplasm + RAC1@Cytoplasm → MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm
8. 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome → 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Cytoplasm
9. MLST8:​MTOR|​pho:​PRAS40*:​RAC1:​RPTOR@Cytoplasm → MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
10. MLST8:​MTOR|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
11. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
12. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
13. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
14. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome
15. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome
16. PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome + 14-3-3*@Cytoplasm → 14-3-3*:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome

1. gFOXP3@T_cell → rFOXP3@T_cell
2. gMYC@Cytosol → rMYC@Cytosol
3. IFNG@INNATE_IMMUNE_CELL_Cytosol → IFNG@default
4. GZMB@SECRETORY_GRANULE → GZMB@default
5. GZMA@SECRETORY_GRANULE → GZMA@default
6. gIL10@INNATE_IMMUNE_CELL_Cytosol → rIL10@INNATE_IMMUNE_CELL_Cytosol
7. MLST8:​MTOR|​S1261_pho|​emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome
8. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome
9. MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome → MLST8:​MTOR|​S1261_pho|​emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome