Identifiers
14-3-3*
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB
stratifin
HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947 GENECARDS:SFN REACTOME:48913 KEGG:2810 ATLASONC:GC_SFN WIKI:SFN
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH
HUGO:YWHAB, HGNC:12849, ENTREZ:7529, UNIPROT:P31946
HUGO:YWHAG, HGNC:12852, ENTREZ:7532, UNIPROT:P61981
HUGO:YWHAH, HGNC:12853, ENTREZ:7533, UNIPROT:Q04917
HUGO:YWHAE, HGNC:12851, ENTREZ:7531, UNIPROT:P62258
HUGO:YWHAQ, HGNC:12854, ENTREZ:10971, UNIPROT:P27348
HUGO:YWHAZ, HGNC:12855, ENTREZ:7534, UNIPROT:Q6NUR9
HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104
HUGO:SFN HGNC:10773 ENTREZ:2810 UNIPROT:P31947
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / MITOCHONDRIA_OXIDATIVE_STRESS
EMT Senescence / SENESCENCE
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_M_CHECKPOINT
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / HEDGEHOG
Survival / PI3K_AKT_MTOR
Survival / WNT_NON_CANONICAL
References
YWHAB is so-called 14-3-3 alpha/beta
PMID:9069260
PMID:21708191, PMID:21621563, PMID:21533173, PMID:16678438, PMID:16556040
synonym:14-3-3 theta
synonym:14-3-3 zeta
synonym:14-3-3 epsilon
for known differences between these different proteins, cf. notes for each individual reaction
PMID:18481918
PMID:19027299
References
em_emtc_emtc_re1618( EMT Senescence ):
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
IGFfamily exhibits anti-apoptotic activity.
Three IGF1R-induced anti-apoptotic pathways:
1. IRS1-mediated pathway causing activation of PI3K and AKT(PKB) leading to BAD phosphorylation.
Unphosphorylated BAD, by binding to BCLXL and BCL2, neutralizes the protective effect of these 2 later proteins and promotes cell death.
Phosphorylated BAD is sequestered by 14-3-3 protein family and thus unable to bind BCL2 family hence can not promote cell death.
2. After autophosphorylation and thus activation, IGF1R binds and postively influence on 14-3-3 protein family, leading to activation and translocation of c-Raf1 to the mitochondria where it phosphorylates BAD.
3. IGF1R specifically phosphorylates and inhibits ASK1 (MAP3K5)
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
References
rc_re23( Regulated Cell Death ):
PMID:15071501
in COS cells, in HCT116 cells, phosphorylation of SFN and YWHAZ by JNK blocks their interaction with BAX
in vitro recombinant MKK7-JNK can directly phosphorylate YWHAZ
putative JNK phosphorylation sites conserved in YWHAB, YWHAE, YWHAZ, and SFN, but not in YWHAG, YWHAH nor YWHAQ
rc_re27:( Regulated Cell Death ) reactionType:is.a
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / STARVATION_AUTOPHAGY
Regulated Cell Death / CASPASES
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / MOMP_REGULATION
Regulated Cell Death / RCD_GENES
References
rc_re1310:( Regulated Cell Death ) PMID:10411906
References
s_akt1_re200:( Survival ) PMID:20832730
References
s_akt1_re124:( Survival ) PMID:10949026
+ 14-3-3*@Nucleus → CDK1|T161_pho:CyclinB1*@Nucleus
+ CDC25B@Nucleus → ce_s2523
+ CDC25C@Nucleus → ce_s2526
→ 14-3-3*@Nucleus
+ 14-3-3*@Cytosol → 14-3-3*:BAD|pho@Cytosol
→ YWHAB@Cytosol
→ 14-3-3*@Cytosol
+ FOXO3@Nucleus → 14-3-3*:FOXO3@Nucleus
+ p27KIP1*|T198_pho|T157_pho@Nucleus → 14-3-3*|unk:p27KIP1*|T198_pho|T157_pho@Cytosol
→ 14-3-3*@Cytosol
→ 14-3-3*@Cytosol
→ 14-3-3*@Cytosol
→ 14-3-3*@Cytosol
→ 14-3-3*@Cytosol
→ 14-3-3*@Cytosol
→ 14-3-3*@Cytosol
+ 14-3-3*|unk@Cytosol → 14-3-3*|unk:ASK1*|unk|S967_pho@Cytosol
→ 14-3-3*@Cytosol
+ 14-3-3*@Cytosol → rc_s118
→ cleaved~14-3-3*@Cytosol
→ 14-3-3*|pho@Cytosol
→ 14-3-3*|unk@Cytosol
→ 14-3-3*|unk@Cytosol
+ FOXO*|pho|pho@Cytosol → 14-3-3*|unk:FOXO*|pho|pho@Cytosol
+ TSC1:TSC2|pho|T1462_pho|M1_unk@Cytosol → 14-3-3*|unk:TSC1:TSC2|pho|T1462_pho|M1_unk@Cytosol
+ rc_s5649 → rc_s5670 + 14-3-3*|unk:PRAS40*|pho@Cytosol
+ RPTOR|S722_pho|S792_pho@Cytosol → 14-3-3*|unk:RPTOR|S722_pho|S792_pho@Cytosol
+ BimEL*|S87_pho@Cytosol → 14-3-3*|unk:BimEL*|S87_pho@Cytosol
+ 14-3-3*|unk@Cytosol → rc_s3150
+ 14-3-3*@Cytoplasm → su_akt1_s_akt1_s479
14-3-3*:FOXO3|T32_pho|S253_pho|S315_pho@Cytoplasm
→ 14-3-3*@Mitochondria
→ 14-3-3*:BAD|S112_pho|S136_pho@Mitochondria
→ 14-3-3*:BAD|S112_pho|S136_pho|S155_pho@Mitochondria
→ 14-3-3*:BAD|S112_pho|S136_pho|S155_pho@Mitochondria + BCL2-XL*@Mitochondria
→ 14-3-3*:BAD|S112_pho|S136_pho|S155_pho@Cytoplasm
→ 14-3-3*:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho@Cytoplasm
→ 14-3-3*:TSC2|S981_pho|S1130_pho|pho|S1132_pho|pho|S1088_pho|S1086_pho@Cytoplasm
+ 14-3-3*@Cytoplasm → 14-3-3*:TSC2|S981_pho|S1130_pho|pho|S1132_pho|pho|S1088_pho|S1086_pho@Endosome Membrane
→ 14-3-3*@Lipid Raft
→ 14-3-3*:MAPKAP1:MLST8:MTOR:PROTOR*:RICTOR|T1135_pho@Cytoplasm
+ RICTOR|T1135_pho@Cytoplasm → 14-3-3*:RICTOR|T1135_pho@Cytoplasm
+ 14-3-3*@Cytoplasm → 14-3-3*:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho@Membrane Lysosome
+ 14-3-3*@Lipid Raft → 14-3-3*:MAPKAP1:MLST8:MTOR|S2481_pho:PROTOR*:RAC1:RICTOR|T1135_pho@Lipid Raft
+ 14-3-3*@Cytoplasm → 14-3-3*:p27KIP1*|S10_pho|T187_pho|pho@Cytoplasm
+ 14-3-3*@Nucleus → su_akt1_s_akt2_s286
14-3-3*:FOXO1|T24_pho|S256_pho|S319_pho@Cytoplasm
→ 14-3-3*@Cytoplasm + FOXO1|T24_pho|S256_pho|S319_pho@Cytoplasm
+ 14-3-3*@Cytoplasm → 14-3-3*:FOXO4|T28_pho|S193_pho|S258_pho@Cytoplasm
→ 14-3-3*@Nucleus
→ 14-3-3*@Cytoplasm + FOXO3|pho|pho|pho@Cytoplasm
+ 14-3-3*@Nucleus → su_akt1_s_akt2_s25
14-3-3*:FOXO3|pho|pho|pho@Cytoplasm
+ GLI1|S640_pho@Nucleus → su_shh1_s_shh2_s104
+ 14-3-3*@Nucleus → su_shh1_s_shh2_s110
+ GLI3-190*|unk|pho|active@Nucleus → su_shh1_s_shh2_s113
+ 14-3-3*@Cytoplasm → 14-3-3*:RGS3|S264_pho@Cytoplasm
→ 14-3-3*:BAD|pho|pho@Cytoplasm
→ Survival@Mitochondria
→ 14-3-3*:BAD|pho|pho|pho@Cytoplasm
→ BAD|pho|pho@Cytoplasm + 14-3-3*@Cytoplasm
→ 14-3-3*:BAD|pho|pho|pho@Mitochondria
+ 14-3-3*@Nucleus → su_wnc1_s_wnc2_s319
14-3-3*:NFAT*|emp|S289_pho|S272_pho@Cytoplasm